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Cat. No.: HY-182299

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LYP-IN-5

LYP-IN-5 is a lymphoid tyrosine phosphatase (LYP) inhibitor with an IC₅₀ value of 20.6 μM. LYP-IN-5 enhances the phosphorylation of ZAP70 and ERK1/2 following TCR stimulation, and promotes T cell activation. LYP-IN-5 can be used in the research of autoimmune diseases.

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CAS No.: 459853-10-2
Formule: C₂₇H₃₆N₆O
Masse moléculaire:460.61

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Please store the product under the recommended conditions in the Certificate of Analysis.

LYP-IN-5 Chemical Structure

CAS No.: 459853-10-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
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- In Vitro
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform ERK :

In Vitro

LYP-IN-5 (Compound 4) (50 μM; 30-60 min) enhances the early TCR signaling pathway in JTAg-expressing human T cells and increases the phosphorylation levels of Lck Y394, ZAP70 Y319, ERK1/2, and SLP76 Y128^[1].
LYP-IN-5 (50 μM) enhances TCR-induced phosphorylation of Lck Y394 and LAT Y191 in primary human T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Jurkat T antigen (JTAg) human T cell line
Concentration:

50 μM
Incubation Time:

30-60 min pre-incubation; 2 min TCR stimulation
Result:

Increased TCR-induced phosphorylation of Lck at Y394.
Increased TCR-induced phosphorylation of ZAP70 at Y319.
Increased TCR-induced phosphorylation of ERK1/2.
Increased TCR-induced phosphorylation of SLP76 at Y128.

Chemical Information

CAS No. 459853-10-2
Masse moléculaire 460.61
Formule C₂₇H₃₆N₆O
SMILES

O=C1NC2=C(C=C1C(N3CCCC4(CCCCC4)C3)C5=NN=NN5C6CCCC6)C=C(C)C=C2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Stanford SM, et al. Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. J Med Chem. 2011;54(6):1640-1654. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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LYP-IN-5

Voir tous les produits spécifiques à Isoform ERK

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

LYP-IN-5 Related Classifications

HY-182299 Related Classifications