MM-401
Based on 1 publication(s) in Google Scholar
MM-401 is a MLL1 H3K4 methyltransferase inhibitor. MM-401 inhibits MLL1 activity (IC50 = 0.32 μM) by blocking MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, apoptosis and differentiation. MM-401 can be used for the research of MLL leukemia.
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- CAS No.: 1442106-10-6
- Formule: C29H46N8O5
- Masse moléculaire:586.73
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) MM-401
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Activité biologique
Ki: < 1 nM (WDR5); IC50: 0.9 nM (WDR5-MLL1 interaction), 0.32 µM (MLL1)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| KOPN-8 | GI50 |
29.73 μM
Compound: 3; MM-401
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Growth inhibition of human KOPN8 cells assessed as reduction in cell viability after 3 days
Growth inhibition of human KOPN8 cells assessed as reduction in cell viability after 3 days
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[PMID: 26958703] |
| MOLM-13 | GI50 |
23.97 μM
Compound: 3; MM-401
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Growth inhibition of human MOLM13 cells assessed as reduction in cell viability after 3 days
Growth inhibition of human MOLM13 cells assessed as reduction in cell viability after 3 days
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[PMID: 26958703] |
| MV4-11 | GI50 |
12.42 μM
Compound: 3; MM-401
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Growth inhibition of human MV4-11 cells assessed as reduction in cell viability after 3 days
Growth inhibition of human MV4-11 cells assessed as reduction in cell viability after 3 days
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[PMID: 26958703] |
MM-401 maintains high binding affinity to WDR5 with a Ki value of < 1 nM and disrupts WDR5-MLL1 interaction with an IC50 value of 0.9 nM[1].
MM-401 is able to specifically inhibit MLL1 activity (IC50 value of 0.32μM) by blocking MLL1-WDR5 interaction and thus the complex assembly[1].
MM-401 (20 μM; 48 h) specifically inhibits MLL1-dependent H3K4 methylation in cells[1].
MM-401 induces similar changes in MLL-AF9 transcriptome as the MLL1 deletion[1].
MM-401 (10, 20, 40 μM; 48 h) specifically inhibits growth of MLL leukemia cells by inducing cell cycle arrest, apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Murine MLL-AF9 and Hoxa9/Meis1 cells
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Concentration:0, 20, 40 μM
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Incubation Time:48 h
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Result:Specifically induced apoptosis of MLL-AF9 cells.
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Cell Line:Murine MLL-AF9 and Hoxa9/Meis1 cells
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Concentration:10, 20, 40 μM
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Incubation Time:48 h
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Result:Induced prominent G1/S arrest in MLL-AF9 cells in a concentration dependent manner.
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Cell Line:MLL-AF9 cells
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Concentration:20 μM
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Incubation Time:48 h
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Result:Significantly decreased H3K4me, expression of 5 Hox A genes, especially Hoxa9 and Hoxa10.
Chemical Information
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CAS No. 1442106-10-6
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Masse moléculaire 586.73
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Formule C29H46N8O5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Nat Commun
KMT2A associates with PHF5A-PHF14-HMG20A-RAI1 subcomplex in pancreatic cancer stem cells and epigenetically regulates their characteristics. [Abstract]2023 Sep 14;14(1):5685. PMID: 37709746
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MM-401 Related Classifications
HY-19554 Related Classifications
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