country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-162427

Copy Link Print Information

NMS-0963

NMS-0963 (compound 1) is an inhibitor of spleen tyrosine kinase (SYK) with an oral activity and IC₅₀ value of 3 nM. NMS-0963 inhibits BaF3-TEL/SYK cell line proliferative at 27 nM.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2765304-82-1
Formule: C₂₃H₂₉N₇O₃
Masse moléculaire:451.52

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

NMS-0963 Chemical Structure

CAS No.: 2765304-82-1

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

NMS-0963 (compound 1) is an inhibitor of spleen tyrosine kinase (SYK) with an oral activity and IC₅₀ value of 3 nM. NMS-0963 inhibits BaF3-TEL/SYK cell line proliferative at 27 nM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	27 nM Compound: 1; NMS-0963	Antiproliferative activity against mouse BaF3 cells harboring TEL/SYK incubated for 72 hrs by CellTiter-Glo assay Antiproliferative activity against mouse BaF3 cells harboring TEL/SYK incubated for 72 hrs by CellTiter-Glo assay	[PMID: 38604095]
BaF3	IC₅₀	7827 nM Compound: 1; NMS-0963	Antiproliferative activity against IL3 stimulated mouse BaF3 cells harboring TEL/SYK incubated for 72 hrs by CellTiter-Glo assay Antiproliferative activity against IL3 stimulated mouse BaF3 cells harboring TEL/SYK incubated for 72 hrs by CellTiter-Glo assay	[PMID: 38604095]
SU-DHL-6	IC₅₀	702.4 nM Compound: 1; NMS-0963	Antiproliferative activity against human SU-DHL-6 cells incubated for 72 hrs by Celltiter-Glo based assay Antiproliferative activity against human SU-DHL-6 cells incubated for 72 hrs by Celltiter-Glo based assay	[PMID: 38604095]

Chemical Information

CAS No. 2765304-82-1
Masse moléculaire 451.52
Formule C₂₃H₂₉N₇O₃
SMILES

CN1C(C(N[C@@H](C)CN2CCC2)=O)=CC(C3=CC=NC(NC4=CC(OC)=CC(OC)=C4)=N3)=N1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Giovanni Cervi, et al. Discovery and optimization of 4-pyrazolyl-2-aminopyrimidine derivatives as potent spleen tyrosine kinase (SYK) inhibitors. Eur J Med Chem. 2024. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

Obtenir un devis En stock