NY0116
NY0116 is a neuromedin U receptor 2 (NMUR2) agonist with EC50 values of 27.76 μM for hNMUR1 and 13.61 μM for hNMUR2. NY0116 decreases cAMP while stimulating calcium signaling in stably expressing NMUR2 HEK293 cells.
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- CAS No.: 1003000-59-6
- Formule: C22H23N3O
- Masse moléculaire:345.44
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
NY0116 has potent dose-dependent inhibition of cAMP (EC50 of 1.69 nM) in HEK293 cells stably expressing hNMUR2. NY0116 also stimulates calcium signaling in cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male diet induced obese (DIO) C57BL/6J mice age 18 weeks and 8 age[1]
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Dosage:3, 10, 30 mg/kg
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Administration:Subcutaneous injection; for 14 days
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Result:Significantly decreased bodyweight compared to vehicle, whereas mice were maintained on a high-fat diet.
Chemical Information
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CAS No. 1003000-59-6
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Masse moléculaire 345.44
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Formule C22H23N3O
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SMILES
NC(NCCOC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=N
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NY0116 Related Classifications
HY-124681 Related Classifications
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