OB-1
Based on 1 Customer Validation
OB-1 is a stomatin-like protein-3 (STOML3) oligomerization blocker. OB-1 is an effective inhibitor of the self-association of Stomatin, STOML1 and STOML2, but not podocin.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.40%
- CAS No.: 300803-69-4
- Formule: C21H17N3O6
- Masse moléculaire:407.38
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Stomatin, STOML1, STOML2, STOML3[1]
OB-1 (3 h) reduces mechanotransduction currents in in N2a cells with an IC50 of 10 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
OB-1 (250 pmol per paw; s.c.; once) alleviates painful diabetic neuropathy in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57Bl/6N mice[1]
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Dosage:250-500 pmol per paw
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Administration:Subcutaneous injection, once
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Result:Over 40% of Aβ fibers (19/44) lacked a mechanosensitive receptive field, which was significantly different from that in vehicle-injected controls, where less than 7% (5/69 fibers) were found to be insensitive to mechanical stimuli. Reduced touch perception. Reversed tactile allodynia.
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Animal Model:Eight-week-old C57Bl/6 mice, Streptozotocin (HY-13753) model[1]
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Dosage:250 pmol per paw
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Administration:Subcutaneous injection, once
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Result:Substantially reversed the mechanical hypersensitivity 4 h after treatment.
Chemical Information
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CAS No. 300803-69-4
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Appearance Solid
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Masse moléculaire 407.38
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Formule C21H17N3O6
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Color White to off-white
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SMILES
O=C(C1=C(C2=CC=CC=C2)OC3=CC=C(OC4=C([N+]([O-])=O)N=CN4C)C=C13)OCC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 12.73 mg/mL (31.25 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4547 mL | 12.2736 mL | 24.5471 mL | 61.3678 mL |
| 5 mM | 0.4909 mL | 2.4547 mL | 4.9094 mL | 12.2736 mL | |
| 10 mM | 0.2455 mL | 1.2274 mL | 2.4547 mL | 6.1368 mL | |
| 15 mM | 0.1636 mL | 0.8182 mL | 1.6365 mL | 4.0912 mL | |
| 20 mM | 0.1227 mL | 0.6137 mL | 1.2274 mL | 3.0684 mL | |
| 25 mM | 0.0982 mL | 0.4909 mL | 0.9819 mL | 2.4547 mL | |
| 30 mM | 0.0818 mL | 0.4091 mL | 0.8182 mL | 2.0456 mL |
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