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Cat. No.: HY-108975

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OK-1035

OK-1035 is a selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC₅₀ of 100 μM.

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CAS No.: 98293-88-0
Formule: C₁₂H₉N₅O
Masse moléculaire:239.23

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

OK-1035 Chemical Structure

CAS No.: 98293-88-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Protocole (1)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

OK-1035 is a selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC₅₀ of 100 μM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	100 μM Compound: 3 (OK-1035)	Inhibition of DNA-dependent protein kinase (DNA-PK) of HeLa cell nuclear cell extract Inhibition of DNA-dependent protein kinase (DNA-PK) of HeLa cell nuclear cell extract	[PMID: 11597411]

In Vitro

OK-1035 (100 μM) is devoid of inhibitory activity against PI 3-kinase and ATM at a concentration of 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 98293-88-0
Masse moléculaire 239.23
Formule C₁₂H₉N₅O
SMILES

N#CC1=CC(C2=CC=NC=C2)=C(NC1=O)/C=N/N
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Stockley M, et al. Synthesis, crystal structure determination, and biological properties of the DNA-dependent protein kinase (DNA-PK) inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035). Bioorg Med Chem Lett. 2001;11(21):2837-2841. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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