Osteostatin
Osteostatin, a fragment of parathyroid hormone-related protein (PTHrP) 107-111, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis, inhibits collagen-induced arthritis and inhibits osteoclastic bone resorption directly. Osteostatin can be used for inflammation and immunology research.
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- CAS No.: 138949-73-2
- Formule: C27H41N9O8
- Masse moléculaire:619.67
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Osteostatin (100, 250 and 500 nM, 7-9 days) decreases the differentiation of osteoclasts in a concentration-dependent manner[2].
Osteostatin (100, 250 and 500 nM, 7 days) decreases the mRNA levels of cathepsin K, osteoclast associated Ig-like receptor (OSCAR) and NFATc1[2].
Osteostatin (100, 250 and 500 nM, 2 days) inhibits the nuclear translocation of the master transcription factor NFATc1 in osteoclast differentiation [2].
Osteostatin (0.1-100 nM, 2 days) significantly increased cell growth in MC3T3-E1 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PBMCs are cultured with M-CSF and RANKL
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Concentration:100, 250 and 500 nM
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Incubation Time:7-9 days
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Result:Decreased the differentiation of osteoclasts in a concentration-dependent manner, but it does not modify the resorptive ability of mature osteoclasts.
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Cell Line:PBMCs are cultured with M-CSF and RANKL
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Concentration:100, 250 and 500 nM
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Incubation Time:7 days
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Result:Decreased the mRNA levels of cathepsin K, osteoclast associated Ig-like receptor (OSCAR) and NFATc1.
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Cell Line:PBMCs are cultured with M-CSF and RANKL
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Concentration:100, 250 and 500 nM
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Incubation Time:2 days
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Result:Inhibited the nuclear translocation of the master transcription factor in osteoclast differentiation NFATc1.
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Cell Line:MC3T3-E1 cells
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Concentration:0-100 nM
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Incubation Time:2 days
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Result:Significantly increased cell growth of MC3T3-E1 cells
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Collagen-induced arthritis in male DBA/1 mice[4]
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Dosage:80 or 120 μg/kg
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Administration:After the onset of disease s.c. every day for 13 days
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Result:Reduced serum IgG2a levels as well as T cell activation, with the downregulation of RORγt+CD4+ T cells and upregulation of FoxP3+CD8+ T cells in lymph nodes.
Decreased the levels of key cytokines, such as interleukin (IL)-1β, IL-2, IL-6, IL-17, and tumor necrosis factor-α in mice paws, whereas enhanced IL-10.
Chemical Information
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CAS No. 138949-73-2
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Masse moléculaire 619.67
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Formule C27H41N9O8
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Synonyms
PTHrP (107–111)
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Sequence
Thr-Arg-Ser-Ala-Trp
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Sequence Shortening
TRSAW
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Fenton AJ, et.al. A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP[107-111]. Endocrinology. 1991 Dec;129(6):3424-6. [Content Brief]
[2]. Ibáñez L, et.al. Osteostatin Inhibits M-CSF+RANKL-Induced Human Osteoclast Differentiation by Modulating NFATc1. Int J Mol Sci. 2022 Aug 1;23(15):8551. [Content Brief]
[3]. Lozano D, et.al. Osteostatin-loaded bioceramics stimulate osteoblastic growth and differentiation. Acta Biomater. 2010 Mar;6(3):797-803. [Content Brief]
[4]. Nácher-Juan J, et.al. Osteostatin Inhibits Collagen-Induced Arthritis by Regulation of Immune Activation, Pro-Inflammatory Cytokines, and Osteoclastogenesis. Int J Mol Sci. 2019 Aug 7;20(16):3845. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Osteostatin Related Classifications
HY-P4684 Related Classifications
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