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Cat. No.: HY-P11870

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PADI4_7

PADI4_7 is an inert binder of peptidylarginine deiminase IV (PADI4) with a K_d value of 8 nM. PADI4_7 binds to PADI4 but does not modulate its catalytic activity. PADI4_7 can be functionalized into a biotinylated probe (bio-PADI4_7), which enriches intracellular PADI4 from cell extracts for biochemical analyses, including the identification of PADI4-interacting proteins under resting or activated conditions.

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Formule: C₈₄H₁₁₀N₁₈O₁₉S
Masse moléculaire:1707.95

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PADI4_7 Chemical Structure

Stock

Quantité

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

PADI4

8 nM (Kd)

In Vitro

PADI4_7 (30 μM) is an inert binder that does not modulate the catalytic activity of recombinant PADI4 in vitro^[1].
Biotinylated PADI4_7 (bio-PADI4_7) specifically enriches human PADI4 from lysates of mES cells stably expressing hPADI4, enabling the isolation of intracellular PADI4 for biochemical analysis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Masse moléculaire 1707.95
Formule C₈₄H₁₁₀N₁₈O₁₉S
SMILES

O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N2[C@@H](CCC2)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CO)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(NCC(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC6=CC=CC=C6)C(N[C@@H](CSC7)C(NCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@@H](CC8=CC=C(C=C8)O)NC7=O
Sequence

{dTyr}-Tyr-Pro-Lys-Gly-Ser-Trp-Gly-Tyr-Lys-Leu-Phe-Cys-Gly-NH2 (thioether bond:dTyr1-Cys13)
Sequence Shortening

{dTyr}-YPKGSWGYKLFCG-NH2 (thioether bond:dTyr1-Cys13)
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Bertran MT, et al. A cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV regulation. Nat Commun. 2024;15(1):9746. Published 2024 Nov 11. [Content Brief]

[2]. Bertran M T, et al. A cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV (PADI4) regulation[J]. BioRxiv, 2023: 2023.12. 12.571217.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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