PCTR1
PCTR1 is a potent monocyte/macrophage agonist, regulating key anti-inflammatory and pro-resolving processes during bacterial infection. PCTR1 is a member of the protectin family of specialized pro-resolving mediators (SPMs).
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- CAS No.: 1810710-59-8
- Formule: C32H47N3O9S
- Masse moléculaire:649.80
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
PCTR1 is a peptide-containing lipid mediator. PCTR1 is temporally regulated during self-limited inflammation and promotes the resolution of bacterial infection. PCTR1 significantly decreases prostaglandin (PG)E2 (48%), PGD2 (64%), PGF2α (38%), and thromboxane B2 (40%). PCTR1 increases exudate macrophage levels, accelerates clearance of E. coli infection, decreases local inflammatory mediator production, and promotes resolution[1].
PCTR1 is an agonist of human keratinocyte migration and has unique structural features that impart this agonist activity. PCTR1 enhances human keratinocyte migration in a cAMP/PKA-dependent manner. Stimulation of keratinocytes with PCTR1 (10 nM; 15 minutes) significantly elevates levels of cAMP[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Primary human epidermal keratinocytes (HPEKp)
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Concentration:0.1, 1, and 10 nM
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Incubation Time:24 hours
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Result:In comparison with untreated cells in which approximately 25% of the initially wounded area was covered by cells 24 hours after wounding, 10 nM significantly enhanced migration such that approximately 46% of the wound area was covered by cells at 24 hours after wounding.
PCTR1 (50?ng/mice) improves the survival rate in an LPS-induced acute inflammatory mouse model[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J wild-type male mice (8-10 weeks old, 22-25 g)[3]
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Dosage:50 ng/mice
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Administration:Administered via the tail vein 1 h after LPS (15 mg/kg) intraperitoneal injection. The survival rate was recorded every day for 7 days
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Result:Compared with the LPS group, the survival rate was significantly higher in the LPS + PCTR1 group, indicating that PCTR1 markedly increases the survival rate.
Chemical Information
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CAS No. 1810710-59-8
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Masse moléculaire 649.80
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Formule C32H47N3O9S
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SMILES
CC/C=C\C[C@@H]([C@@H](/C=C/C=C/C=C\C/C=C\C/C=C\CCC(O)=O)SC[C@H](NC(CC[C@H](N)C(O)=O)=O)C(NCC(O)=O)=O)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Sesquile Ramon, et al. The Protectin PCTR1 Is Produced by Human M2 Macrophages and Enhances Resolution of Infectious Inflammation. Am J Pathol. 2016 Apr;186(4):962-73. [Content Brief]
[2]. Brian E Sansbury, et al. PCTR1 Enhances Repair and Bacterial Clearance in Skin Wounds. Am J Pathol. 2021 Jun;191(6):1049-1063. [Content Brief]
[3]. Yong-Jian Liu, et al. PCTR1 ameliorates lipopolysaccharide-induced acute inflammation and multiple organ damage via regulation of linoleic acid metabolism by promoting FADS1/FASDS2/ELOV2 expression and reducing PLA2 expression. Lab Invest. 2020 Jul;100(7):904-915. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PCTR1 Related Classifications
HY-125445 Related Classifications
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