PD13

PD13 (10 μg/mL; 2 days) inhibits succinate dehydrogenase activity in M. oryzae Guy11 mycelia, reducing the activity by 89.3%^[1].
PD13 (10 μg/mL; treatment at 25 °C for 30 minutes) reduces the apparent V_max of MoSDH from 41.02 to 10.79 U/g and increases the apparent K_m from 3.219 to 4.415 mM^[1].
PD13 (10 μg/mL) reduces the conidial germination rate of Guy11 to 68% and the appressorium formation rate to 7%, whereas the point mutants exhibit reduced sensitivity^[1].
PD13 (100 μg/mL; 24 h before inoculation; 7 days) reduces the overall necrotic lesion area of rice blast by 89%, and by 85% in Guy11, whereas the point mutants exhibit reduced sensitivity^[1].
PD13 remains active against the SDHI cross-resistant M. oryzae strain SX245, whereas the point mutants exhibit reduced sensitivity^[1].
PD13 (100 μg/mL; 24 h before inoculation; 5-12 days) exhibits only partial protective activity against tomato gray mold and Fusarium head blight, which is weaker than its activity against rice blast^[1].
PD13 (300 g/ha) reduces the rice blast disease index by 25% in field trials^[1].
PD13 (50-100 μg/mL) does not impair the growth of yeast strains AH109 or XK125^[1].

Binding of PD13 to MoSDH decreases by approximately 50% in ΔMosdhBA and is almost lost in ΔMosdhD2A mitochondria^[1].