Pep2-SVKE
Pep2-SVKE is an inactive control peptide for pep2-SVKI (HY-P1056). Pep2-SVKE is an inhibitory peptide corresponding to the last 10 amino acids of the C-terminus of the GluR2 AMPA receptor subunit. Pep2-SVKE does not block AMPA-mediated [3H]DA exocytosis. Pep2-SVKE does not bind to GRIP or PICK43 and does not block retention of PICK1 by GST-GluR2 and LTD[1][2][3][4][5].
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- CAS No.: 1315378-76-7
- Formule: C59H89N13O20
- Masse moléculaire:1300.41
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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AMPA Receptor |
Pep2-SVKE (100 μM) does not block mGluR-LTD in dopaminergic (DA) neurons[1].
Pep2-SVKE (1 mM) does not bind to PICK or GRIP46, nor does it inhibit the increase in EPSC amplitude ratio (R+40/-60mV) induced by active peptides[2].
Pep2-SVKE (1 mM) does not bind to GRIP or PICK43, nor does it alter mEPSC amplitude and AMPA- and NMDA-induced [3H]ACh release at somatic AMPAR receptors[2][4].
Pep2-SVKE (1 μM) does not alter the dramatic reduction in [3H]DA efflux[3].
Pep2-SVKE does not abolish AMPA receptor sensitivity to cyclothiazide, which controls the release of [3H] nucleoside analogs (NA)[4].
Pep2-SVKE (133 μM) does not block the retention of PICK1 by GST-GluR2 and LTD[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1315378-76-7
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Masse moléculaire 1300.41
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Formule C59H89N13O20
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Sequence
Tyr-Asn-Val-Tyr-Gly-Ile-Glu-Ser-Val-Lys-Glu
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Sequence Shortening
YNVYGIESVKE
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Mameli M, et al. Rapid synthesis and synaptic insertion of GluR2 for mGluR-LTD in the ventral tegmental area. Science. 2007 Jul 27;317(5837):530-3. [Content Brief]
[2]. Liu SJ, et al. Subunit interaction with PICK and GRIP controls Ca2+ permeability of AMPARs at cerebellar synapses. Nat Neurosci. 2005 Jun;8(6):768-75. [Content Brief]
[3]. Grilli M, et al. In vitro exposure to nicotine induces endocytosis of presynaptic AMPA receptors modulating dopamine release in rat nucleus accumbens nerve terminals. Neuropharmacology. 2012 Oct;63(5):916-26. [Content Brief]
[4]. Pittaluga A, et al. Trafficking of presynaptic AMPA receptors mediating neurotransmitter release: neuronal selectivity and relationships with sensitivity to cyclothiazide. Neuropharmacology. 2006 Mar;50(3):286-96. [Content Brief]
[5]. Daw MI, et al. PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Neuron. 2000 Dec;28(3):873-86. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pep2-SVKE Related Classifications
HY-P1055 Related Classifications
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