PI-16
PI-16 is a selective uroporphyrinogen decarboxylase (UROD) inhibitor with an IC50 of 9.9 µM against human UROD. PI-16 inhibits the heme biosynthesis enzyme that converts uroporphyrinogen to coproporphyrinogen. PI-16 selectively reduces the viability of hypopharyngeal squamous cell carcinoma and cervical cancer cells. PI-16 can be used in combination with Cisplatin (HY-17394), with synergistic effects observed in hypopharyngeal squamous cell carcinoma cells. PI-16 can be used in research related to hypopharyngeal squamous cell carcinoma and cervical cancer.
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- CAS No.: 1654761-54-2
- Formule: C40H48N4O8
- Masse moléculaire:712.84
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| FaDu | EC50 |
22.7 μM
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PI-16-induced viability reduction in human hypopharyngeal squamous carcinoma FaDu cells measured by ATPlite assay after 24 hrs seeding.
PI-16-induced viability reduction in human hypopharyngeal squamous carcinoma FaDu cells measured by ATPlite assay after 24 hrs seeding.
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24587102 |
| ME-180 | EC50 |
26.9 μM
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PI-16-induced viability reduction in human cervical carcinoma ME-180 cells measured by ATPlite assay after 24 hrs seeding.
PI-16-induced viability reduction in human cervical carcinoma ME-180 cells measured by ATPlite assay after 24 hrs seeding.
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24587102 |
In Vitro
PI-16 (24 h) combined with cisplatin is potently synergistic in FaDu cells (CI<1), and PI-16 with radiation or cisplatin shows at-least-additive/more-than-additive effects in FaDu and ME-180 clonogenic assays[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1654761-54-2
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Masse moléculaire 712.84
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Formule C40H48N4O8
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SMILES
O=C(O)CCC=1C=2N=C(C1C)C(C=3NC(C=C4N=C(C(=C4CCC(=O)O)C)C(C=5NC(C2)=C(C5C)CCC(=O)O)(C)C)=C(C3C)CCC(=O)O)(C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PI-16 Related Classifications
HY-134605 Related Classifications
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