(+)-trans-C75
(+)-trans-C75 ((+)-C75) is an enantiomer of C75 (HY-12364) (a fatty acid synthase inhibitor). (+)-trans-C75 is less potent than the racemic mixture or the (-) enantiomer in enhancing the cancer-killing ability of ionizing radiation. (+)-trans-C75 inhibits CPT1 and is an anorectic agent.
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- CAS No.: 1234694-20-2
- Formule: C14H22O4
- Masse moléculaire:254.32
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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CPT-1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | IC50 |
32.43 μM
Compound: 9, C75
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Inhibition of FASN in human A375 cells
Inhibition of FASN in human A375 cells
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[PMID: 21726077] |
| KB | IC50 |
36.5 μM
Compound: 55, C75
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Cytotoxicity in human KB cells
Cytotoxicity in human KB cells
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[PMID: 21504156] |
Chemical Information
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CAS No. 1234694-20-2
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Masse moléculaire 254.32
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Formule C14H22O4
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SMILES
O=C([C@@H](C1=C)[C@@H](CCCCCCCC)OC1=O)O
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Synonyms
(+)-C75
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Rae C, et al. Differential in radiosensitizing potency of enantiomers of the fatty acid synthase inhibitor C75. Chirality. 2017 Jan;29(1):10-13. [Content Brief]
[2]. Makowski K, et al. Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity. Chirality. 2013 May;25(5):281-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(+)-trans-C75 Related Classifications
HY-12364C Related Classifications
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