CD1d
CD1d is the single group 2 member of the CD1 family and the presenting molecule for invariant natural killer T (iNKT) cells. It binds lipid antigens in a deep hydrophobic groove and displays them to the semi-invariant TCR of iNKT cells; the marine sponge glycosphingolipid alpha-galactosylceramide is the prototypical agonist. Endogenous ligands include lysophospholipids and beta-glucosylceramide, while microbial ligands derive from Sphingomonas bacteria and mycobacteria. CD1d is broadly expressed on hematopoietic cells, including B cells, monocytes, and dendritic cells, and is inducible on epithelia. Through iNKT cell activation CD1d shapes Th1/Th2 balance, antitumor immunity, and autoimmunity, and CD1d-deficient mice lose iNKT cells entirely.
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CD1d Protéines Recombinantes (5)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
