IgG2C
IgG2c is a mouse IgG subclass present in C57BL/6, NOD, and related laboratory strains, where it occupies the locus held by IgG2a in BALB/c-type genomes, so the two genes are essentially strain-specific allelic variants rather than independent subclasses. Like IgG2a, IgG2c supports Th1-type humoral responses and binds activating Fc gamma receptors including Fc gamma RIV, mediating strong effector functions in models of infection and autoimmunity. IgG2c antibodies predominate in lupus-prone mice and contribute to glomerulonephritis pathogenesis. Researchers must account for the IgG2a-versus-IgG2c strain difference when choosing isotype controls, assay reagents, and Fc engineering strategies in murine studies.
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IgG2C Protéines Recombinantes (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
