TXK
TXK, also called RLK (resting lymphocyte kinase), is a Tec-family non-receptor tyrosine kinase expressed in T lymphocytes, natural killer cells and mast cells. It is structurally unique among Tec kinases: the N-terminal pleckstrin-homology domain is replaced by a cysteine-rich region that permits palmitoylation, conferring constitutive membrane localization independent of PI3K-generated PIP3. Acting with ITK downstream of the T-cell receptor, TXK phosphorylates PLCγ, while its hallmark function is promoting T-helper-1 responses: TXK translocates to the nucleus and directly boosts interferon-gamma gene transcription. Concordantly, TXK overactivity has been linked to systemic lupus erythematosus. Pharmacologically, TXK is inhibited by dasatinib and by the irreversible inhibitor ibrutinib to a modest degree.
-
TXK Protéines Recombinantes (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
