Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres

  • Bioorg Med Chem. 2007 Aug 15;15(16):5615-9. doi: 10.1016/j.bmc.2007.05.033.
François Liger  1 ,  Florence Popowycz ,  Thierry Besson ,  Laurent Picot ,  Carlos M Galmarini ,  Benoît Joseph
Affiliations
  • 1. Laboratoire de Chimie Organique 1, UMR - CNRS 5181, Université Claude Bernard - Lyon 1, Bâtiment 308 - CPE, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne Cedex, France.
PMID: 17548198 DOI: 10.1016/j.bmc.2007.05.033
Abstract

Aza-analogues of clausine E, mukonine and koenoline were prepared from 1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde and their antiproliferative activity was evaluated against miscellaneous Cancer cell lines and compared to those obtained with clausine E and mukonine.

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