S2/IAPinh
S2/IAPinh is a conjugate, which consist of an inhibitor for the apoptosis protein inhibitor (IAPinh) and a ligand for sigma 2 SW43. S2/IAPinh exhibits an anti-proliferative and apoptotic-inducing effect through degradation of the cellular inhibitor for apoptosis protein (clAP-1).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C52H75Cl2FN6O6S
- Masse moléculaire:1002.16
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Protocole
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Description
In Vitro
S2/IAPinh (0-100 μM) exhibits cytotoxicity in cancer cells Human pancreatic cancer cell lines AsPC-1, HPAC and MiaPaCa-2, mouse pancreatic cancer cell lines KP2 and human ovarian cancer cell lines OVCAR3/8 with IC50s from 4.6 to 12.8 μM, and induces apoptosis in HPAC and OVCAR8 through activation of caspase 3 and caspase 8[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:KP-2 xenograft C57BL/6 mice and OVCAR8 xenograft athymic nude mice[1]
-
Dosage:25 µmol/ kg
-
Administration:i.p., daily for 21 days
-
Result:Inhibited tumor growth and improved the mice survival rate without body weight loss.
Chemical Information
-
Masse moléculaire 1002.16
-
Formule C52H75Cl2FN6O6S
-
SMILES
O=C(OC1CC(N2CCCCCCCCCCNC(C)C(N[C@H](C(N3CCC[C@@]3([H])C4=NC(C(C5=CC=C(F)C=C5)=O)=CS4)=O)C6CCCCC6)=O)CCCC2C1)NC7=C(OC)C=CC(C)=C7.Cl.Cl
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
S2/IAPinh Related Classifications
HY-158076 Related Classifications
Powered by Bioz