SB26019
SB26019 is a potent anti-neuroinflammatory agent. SB26019 regulates NF-κB activation by inducing monomeric α-tubulin formation. SB26019-induced α-tubulin monomer inhibits p65 translocation.
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- CAS No.: 1233078-90-4
- Formule: C24H20O4
- Masse moléculaire:372.41
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
SB26019 (10 μM; for 6 h) suppresses the production of inflammatory marker genes, such as Ccl2, Cxcl10, Il-1β, Il-6, Nos2, and Tnf[1].
SB26019 (1.25-10 μM; 1-12 h) induces IκB degradation in a time- and dose-dependent manner[1].
SB26019 (IC50 of 1.13 μM) produces more significant amounts of α-tubulin monomers and fewer tubulin polymers than the less potent anti-inflammatory regulator colchicine (IC50 of 4.20 μM)[1].
SB26019 (10 μM)-induced α-tubulin monomer inhibits p65 translocation in J774A.1 and RAW264.7 murine macrophage cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BV-2 murine microglial cells
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Concentration:10 μM
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Incubation Time:6 h
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Result:Suppressed the production of inflammatory marker genes.
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Cell Line:J774A.1 cells
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Concentration:1.25 μM, 2.5 μM, 5 μM, 10 μM
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Incubation Time:1 h, 3 h, 6 h, 12 h
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Result:Dose- and time-dependent IκB degradation without affecting the total amount of p65 in J774A.1 cells.
Pharmacokinetic (PK) analysis of SB26019[1].
| Parameters | I.P.,5 mg/kg |
| Tmax (h) | 0.17 ± 0.00 |
| Cmax (μg/mL) | 1.20 ± 0.26 |
| T1/2 (h) | 3.57 ± 0.62 |
| AUCt (μg h/mL) | 1.77 ± 0.30 |
| AUC∞ (μg h/mL) | 1.79 ± 0.31 |
| CL (L/h/kg) | NA |
| Vss (L/kg) | NA |
| Ft (%) | NA |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:10-week-old female C57BL/6 mice (20-25 g)[1]
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Dosage:2 mg/kg, 5 mg/kg
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Administration:i.p; daily; for 4 days
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Result:Suppressed microglial activation by downregulating lba-1 and proinflammatory cytokines.
Chemical Information
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CAS No. 1233078-90-4
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Masse moléculaire 372.41
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Formule C24H20O4
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SMILES
COC1=CC=C2C(C3=C4OC5=C(C4=CC=C3)C=CC=C5)=CC(C)(OC2=C1O)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SB26019 Related Classifications
HY-152089 Related Classifications
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