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Cat. No.: HY-181544

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SB5-171

SB5-171 is a covalent PfCLK3 inhibitor with IC₅₀ values of 10-12 nM. SB5-171shows antiparasitic activity. SB5-171 can be used for the research of malaria.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 3088376-92-2
Formule: C₂₉H₃₁N₅O₇S
Masse moléculaire:593.65

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

SB5-171 Chemical Structure

CAS No.: 3088376-92-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

SB5-171 is a covalent PfCLK3 inhibitor with IC₅₀ values of 10-12 nM. SB5-171shows antiparasitic activity. SB5-171 can be used for the research of malaria^[1].

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In Vitro

SB5-171 (Compound 14) potently inhibits recombinant full-length PfCLK3 with apparent IC₅₀ values of 10 nM at K_m ATP and 12 nM at 3 mM ATP^[1].
SB5-171 (100 pM-100 μM; 72 h) potently inhibits asexual blood stage growth of P. falciparum 3D7 (EC₅₀ = 104 nM) and chloroquine-resistant Dd2 (EC₅₀ = 267 nM) strains^[1].
SB5-171 (24-48 h) has low cytotoxicity, with a CC₅₀ of >100 μM in HepG2 cells and 25 μM in THP-1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3088376-92-2
Masse moléculaire 593.65
Formule C₂₉H₃₁N₅O₇S
SMILES

O=C(O)C1=CC=C(C2=C3C(NC(C4=CC(CN5CCN(C(COS(=O)(NC)=O)=O)CC5)=CC=C4OC)=C3)=NC=C2)C=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Brettell SB, et al. Shaping Antimalarials: A Geometry-First Approach to PfCLK3 Covalent Inhibitors. J Med Chem. 2026;69(3):3378-3395. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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