Sematilide
Sematilide (CK-1752) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM). Sematilide is a class III antiarrhythmic agent.
At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Sematilide hydrochloride) usually boasts enhanced water solubility and stability.
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- CAS No.: 101526-83-4
- Formule: C14H23N3O3S
- Masse moléculaire:313.42
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Other In-stock Forms of Sematilide
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
IC50: 25 μM (K+ current)[1]
In Vitro
Application of 10, 30, 100 and 300 μM Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mongrel dogs of either sex (10-18 kg body weight)[2]
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Dosage:0.3, 1, 3, and 10 mg/kg
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Administration:I.v. infusions
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Result:Demonstrated antiarrhythmic effects at 0.3 and 3.0 mg/kg.
Chemical Information
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CAS No. 101526-83-4
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Masse moléculaire 313.42
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Formule C14H23N3O3S
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SMILES
O=C(NCCN(CC)CC)C1=CC=C(NS(=O)(C)=O)C=C1
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Synonyms
CK-1752
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sematilide Related Classifications
HY-101436 Related Classifications
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