SFI003
Based on 1 Customer Validation
SFI003 is a SRSF3 inhibitor that drives CRC cell apoptosis via the SRSF3/DHCR24/ROS axis and exhibits potent antitumor effects both in vitro and in vivo.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.75%
- CAS No.: 2361332-90-1
- Formule: C19H17N5OS
- Masse moléculaire:363.44
-
Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Pureté et documentation
- Références
-
Help & FAQs
-
Apoptosis Compound Library
HY-L003
-
Immunology/Inflammation Compound Library
HY-L007
-
Metabolism/Protease Compound Library
HY-L012
-
NF-κB Signaling Compound Library
HY-L014
-
Anti-Cancer Compound Library
HY-L025
-
Anti-Aging Compound Library
HY-L034
-
Cysteine Targeted Covalent Library
HY-L153
-
Cell Death Library
HY-L162
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
-
High-Throughput Bioactive Compound Library
HY-L205
-
Lactylation Compound Library
HY-L249
Activité biologique
SFI003 (0-50 μM, 0-72 h) inhibits the proliferation of HCT116 and SW480 cells in a dose- and time-dependent manner with IC50values of 8.78 µM and 48.67 µM, respectively[1].
SFI003 (0-50 μM, 24-72 h) induces apoptosis in HCT-116 and SW480 cells[1].
SFI003 (0-50 μM, 24-72 h) induces ROS generation in both HCT-116 and SW480 cells in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HCT-116 and SW480 cells
-
Concentration:10, 20, 50 μM
-
Incubation Time:24, 48, 72 h
-
Result:Inhibited the activity of Akt (p-Akt) and mTOR (p-mTOR).
Inhibited DHCR24 protein expression.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Subcutaneous injection of HCT-116 and SW480 cells into aplastic male SCID mice[1]
-
Dosage:100 and 200 mg/kg
-
Administration:Oral gavage (p.o.) for two weeks
-
Result:At a dose of 200 mg/kg, the tumors in half of the mice disappeared, and at a dose of 100 mg/kg, the tumors in some mice also disappeared.
Chemical Information
-
CAS No. 2361332-90-1
-
Appearance Solid
-
Masse moléculaire 363.44
-
Formule C19H17N5OS
-
Color Yellow to brown
-
SMILES
COC(C=C1)=CC=C1C2=CSC(N/N=C(C3=NC4=CC=CC=C4N3)\C)=N2
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 125 mg/mL (343.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
-
Fiche technique (272 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7515 mL | 13.7574 mL | 27.5149 mL | 68.7871 mL |
| 5 mM | 0.5503 mL | 2.7515 mL | 5.5030 mL | 13.7574 mL | |
| 10 mM | 0.2751 mL | 1.3757 mL | 2.7515 mL | 6.8787 mL | |
| 15 mM | 0.1834 mL | 0.9172 mL | 1.8343 mL | 4.5858 mL | |
| 20 mM | 0.1376 mL | 0.6879 mL | 1.3757 mL | 3.4394 mL | |
| 25 mM | 0.1101 mL | 0.5503 mL | 1.1006 mL | 2.7515 mL | |
| 30 mM | 0.0917 mL | 0.4586 mL | 0.9172 mL | 2.2929 mL | |
| 40 mM | 0.0688 mL | 0.3439 mL | 0.6879 mL | 1.7197 mL | |
| 50 mM | 0.0550 mL | 0.2751 mL | 0.5503 mL | 1.3757 mL | |
| 60 mM | 0.0459 mL | 0.2293 mL | 0.4586 mL | 1.1465 mL | |
| 80 mM | 0.0344 mL | 0.1720 mL | 0.3439 mL | 0.8598 mL | |
| 100 mM | 0.0275 mL | 0.1376 mL | 0.2751 mL | 0.6879 mL |
SFI003 Related Classifications
HY-148660 Related Classifications
Powered by Bioz