sulfo-SPDB-DM4
Based on 1 publication(s) in Google Scholar
sulfo-SPDB-DM4 is a agent-linker conjugate for ADC by using the maytansinebased payload (DM4, an antitubulin agent) via the sulfo-SPDB linker.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.81%
- CAS No.: 1626359-59-8
- Formule: C46H63ClN4O17S3
- Masse moléculaire:1075.66
-
Stockage:
-80°C, protect from light, stored under nitrogen
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Pureté et documentation
- Références
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) sulfo-SPDB-DM4
MoreVoir tous les produits spécifiques à Isoform Drug-Linker Conjugates for ADC
More
Activité biologique
|
Maytansinoids |
DM4, a structural analogue of maytansine, is a new thiol-containing and potent maytansinoid. DM4 is a cytotoxic maytansinoid drug. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Maytansinoids inhibit tubulin polymerization and microtubule assembly and enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1626359-59-8
-
Appearance Solid
-
Masse moléculaire 1075.66
-
Formule C46H63ClN4O17S3
-
Color White to yellow
-
SMILES
C[C@]1([C@@](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)([H])OC([C@H](C)N(C)C(CCC(C)(C)SSCCC(S(=O)(O)=O)C(ON(C4=O)C(CC4)=O)=O)=O)=O)[C@H]([C@@H]([C@](OC5=O)([H])C[C@]([C@](/C=C/C=C(C)/C2)([H])OC)(N5)O)C)O1
-
Livraison
Shipping with dry ice.
-
Stockage
-80°C, protect from light, stored under nitrogen
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Clin Cancer Res
ZW191, an FRα-Targeted Topoisomerase 1 Inhibitor ADC with a Differentiated Antitumor Efficacy and Tolerability Profile. [Abstract]2026 Jul 1;32(13):2748-2764. PMID: 42007996
Solvant et solubilité
DMSO : 50 mg/mL (46.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
-
Fiche technique (277 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9297 mL | 4.6483 mL | 9.2966 mL | 23.2415 mL |
| 5 mM | 0.1859 mL | 0.9297 mL | 1.8593 mL | 4.6483 mL | |
| 10 mM | 0.0930 mL | 0.4648 mL | 0.9297 mL | 2.3242 mL | |
| 15 mM | 0.0620 mL | 0.3099 mL | 0.6198 mL | 1.5494 mL | |
| 20 mM | 0.0465 mL | 0.2324 mL | 0.4648 mL | 1.1621 mL | |
| 25 mM | 0.0372 mL | 0.1859 mL | 0.3719 mL | 0.9297 mL | |
| 30 mM | 0.0310 mL | 0.1549 mL | 0.3099 mL | 0.7747 mL | |
| 40 mM | 0.0232 mL | 0.1162 mL | 0.2324 mL | 0.5810 mL |
sulfo-SPDB-DM4 Related Classifications
HY-101141 Related Classifications
Powered by Bioz