T 162559
T 162559 is a potent and selective inhibitor of the Na+/H+ exchanger isoform NHE1 with IC50 values of 0.96 nM. T 162559 does not affect Na+/HCO3- cotransport and Na+/Ca2+ exchange. T 162559 can be used for the research of cardiovascular disease.
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- CAS No.: 339532-12-6
- Formule: C20H28FN5O6S2
- Masse moléculaire:517.59
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
T-162559 (10-100 nmol/L, continuous infusion started 10 minutes before the induction of global ischemia) concentration-dependently inhibits the reduction in cardiac contractility, progression of cardiac contracture, and increase in lactate dehydrogenase release after global ischemia and reperfusion[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 339532-12-6
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Masse moléculaire 517.59
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Formule C20H28FN5O6S2
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SMILES
CS(=O)(O)=O.CS(=O)(O)=O.CC1=C([C@@H]2C/C(C3=C(C)C=CN=C3C2)=N\NC(N)=N)C=C(F)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Kawamoto T, et al. Potent and selective inhibition of the human Na+/H+ exchanger isoform NHE1 by a novel aminoguanidine derivative T-162559. Eur J Pharmacol. 2001 May 18;420(1):1-8. [Content Brief]
[2]. Kusumoto K, et al. In vitro and in vivo pharmacology of a structurally novel Na+-H+ exchange inhibitor, T-162559. Br J Pharmacol. 2002 Apr;135(8):1995-2003. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
T 162559 Related Classifications
HY-105402 Related Classifications
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