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Cat. No.: HY-11085

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T-226296

T-226296 is an oral active and selective melanin-concentrating hormone receptor antagonist with the IC₅₀ values of 5.5 nM and 8.6 nM for human SLC-1 and rat SLC-1, respectively. T-226296 can be used for study of obesity and insulin resistance.

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CAS No.: 331758-35-1
Formule: C₂₆H₂₇FN₂O
Masse moléculaire:402.50

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

T-226296 Chemical Structure

CAS No.: 331758-35-1

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	14 nM Compound: 1h	Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation counting Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation counting	[PMID: 21856163]
CHO	IC₅₀	24 nM Compound: 1h	Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting	[PMID: 21856163]
CHO	IC₅₀	43 nM Compound: 1h	Antagonist activity at human MCHR1 expressed in CHO cells assessed as inhibition of MCH-induced GTPgammaS binding after 60 mins by scintillation counting Antagonist activity at human MCHR1 expressed in CHO cells assessed as inhibition of MCH-induced GTPgammaS binding after 60 mins by scintillation counting	[PMID: 21856163]
CHO	IC₅₀	5.5 nM Compound: 1, T-226296	Displacement of [125I]MCH from human MCHR1 expressed in CHO cells by competition binding assay Displacement of [125I]MCH from human MCHR1 expressed in CHO cells by competition binding assay	[PMID: 21190859]
CHO	IC₅₀	5.5 nM Compound: 7	Inhibition of Melanin-concentrating hormone 1 receptor expressed in CHO cells Inhibition of Melanin-concentrating hormone 1 receptor expressed in CHO cells	[PMID: 15267235]
CHO	IC₅₀	5.5 nM Compound: T-226296	Displacement of [125I]-MCH(4-19) from human MCHR1 expressed in CHO cells Displacement of [125I]-MCH(4-19) from human MCHR1 expressed in CHO cells	[PMID: 21975069]
HEK293	IC₅₀	5.5 nM Compound: I, T-226296	Antagonist activity at CART form of human MCH1 receptor expressed in HEK293 cells coexpressing Galphaq assessed as inhibition of MCH-induced intracellular calcium level by FLIPR assay Antagonist activity at CART form of human MCH1 receptor expressed in HEK293 cells coexpressing Galphaq assessed as inhibition of MCH-induced intracellular calcium level by FLIPR assay	[PMID: 19773162]
IMR-32	IC₅₀	872 nM Compound: T-226296 (-)	Concentration required to inhibit 50% of melanin-concentrating hormone induced [Ca2+] flux in IMR-32 cells measured by using a fluorometric imaging plate reader Concentration required to inhibit 50% of melanin-concentrating hormone induced [Ca2+] flux in IMR-32 cells measured by using a fluorometric imaging plate reader	[PMID: 15341943]

Chemical Information

CAS No. 331758-35-1
Masse moléculaire 402.50
Formule C₂₆H₂₇FN₂O
SMILES

O=C(C1=CC=C(C2=CC=C(C=C2)F)C=C1)NC3=CC=C(CC(CC4)CN(C)C)C4=C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Takekawa S, et al. T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist. Eur J Pharmacol. 2002;438(3):129-135. [Content Brief]

Calculators

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Molecular Weight Molecular Weight

Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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