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Ternatin

Ternatin (compound 2) is a cyclic heptapeptides that can be isolated from mushroom Coliorus versicolor. Ternatin inhibits fat-accumulation with an IC₅₀ of 0.027 μM in 3T3-L1 adipocytes.

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CAS No.: 148619-41-4
Formule: C₃₇H₆₇N₇O₈
Masse moléculaire:737.97

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Please store the product under the recommended conditions in the Certificate of Analysis.

Ternatin Chemical Structure

CAS No.: 148619-41-4

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Activité biologique
- Description
- Cellular Effect
- Sequence
- Sequence Shortening
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
3T3-L1	IC₅₀	0.027 μM Compound: 1	Inhibition of fat accumulation in mouse 3T3L1 cells assessed as liberated triglyceride after 7 days Inhibition of fat accumulation in mouse 3T3L1 cells assessed as liberated triglyceride after 7 days	[PMID: 18798610]
3T3-L1	IC₅₀	0.027 μM Compound: 1	Inhibition of fat accumulation in mouse 3T3L1 cells after 7 days Inhibition of fat accumulation in mouse 3T3L1 cells after 7 days	[PMID: 19022665]
3T3-L1	IC₅₀	0.027 μM Compound: 2, cyclo-[D-allo-Ile1-NMe-L-Ala2-NMe-L-Leu3-L-Leu4-NMe-L-Ala5-NMe-D-Ala6-beta-OH-D-Leu7]	Inhibition of fat-accumulation in mouse 3T3L1 cells Inhibition of fat-accumulation in mouse 3T3L1 cells	[PMID: 19097891]
3T3-L1	IC₅₀	0.28 μM Compound: 1	Toxicity in mouse 3T3L1 cells Toxicity in mouse 3T3L1 cells	[PMID: 18798610]
3T3-L1	IC₅₀	0.28 μM Compound: 1	Cytotoxicity against mouse 3T3L1 cells Cytotoxicity against mouse 3T3L1 cells	[PMID: 19022665]
3T3-L1	IC₅₀	0.28 μM Compound: 2, cyclo-[D-allo-Ile1-NMe-L-Ala2-NMe-L-Leu3-L-Leu4-NMe-L-Ala5-NMe-D-Ala6-beta-OH-D-Leu7]	Cytotoxicity against mouse 3T3L1 cells Cytotoxicity against mouse 3T3L1 cells	[PMID: 19097891]

Sequence

Cyclo({Ala(N-Me)}-{d-Ala((N-Me)}-{d-Leu((3R)-3-hydroxy)}-{d-Ile}-{Ala(N-Me)}-Leu-Leu)

Sequence Shortening

Cyclo({Ala(N-Me)}-{d-Ala((N-Me)}-{d-Leu((3R)-3-hydroxy)}-{d-Ile}-{Ala(N-Me)}-Leu-Leu)

Chemical Information

CAS No. 148619-41-4
Masse moléculaire 737.97
Formule C₃₇H₆₇N₇O₈
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Kenichiro Shimokawa, et al. Structure-based hybridization of the bioactive natural products rhizonin A and ternatin leading to a selective fat-accumulation inhibitor against 3T3-L1 adipocytes. Bioorg Med Chem Lett. 2009 Feb 1;19(3):867-9. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Activité biologique
- Description
- Sequence
- Sequence Shortening
Chemical Information
Pureté et documentation
Références

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