TLX agonist 3
TLX agonist 3 is a potent and selective tailless homolog (TLX, NR2E1) agonist with an EC50 of 0.25 μM and a Kd of 1.6 μM). TLX agonist 3 shows high selectivity over related nuclear receptors, and promotes TLX oligomerization with an EC50 of 5.0 μM. TLX agonist 3 can be used for the research of neurodegenerative diseases.
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- CAS No.: 3032232-47-3
- Formule: C25H23F3N4O2
- Masse moléculaire:468.48
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Chemical Information
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Activité biologique
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TLX 0.25 μM (EC50) |
TLX 1.6 μM (Kd) |
TLX agonist 3 (compound 10) (2.5-20 μM; 22 h) enhances TLX oligomerization in a concentration-dependent manner in homogeneous time-resolved fluorescence resonance energy transfer\n(HTRF)-based assay[1].
TLX agonist 3 activates full-length human TLX in HEK293 cells with an EC50 of 0.7 μM[1].
TLX agonist 3 (3 µM; 8 h) induces SIRT1 expression without altering TLX levels in T98G human astrocyte cells cells[1].
TLX agonist 3 (10 µM; 0-60 min) shows favorable microsomal stability (t1/2 = 142 min) in rat liver microsomes[1].
TLX agonist 3 (up to 10 µM; 24 h) shows no pronounced cytotoxic effects in HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:T98G human astrocyte cells
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Concentration:3 μM
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Incubation Time:8 h
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Result:Induced expression of the TLX-regulated gene SIRT1 but did not alter TLX levels.
Chemical Information
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CAS No. 3032232-47-3
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Masse moléculaire 468.48
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Formule C25H23F3N4O2
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SMILES
O=C(NC=1C=C(C=C(C1)C(F)(F)F)N2C=NC(=C2)C)C=3C=C(N=C4C=CC=CC43)OCCCC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TLX agonist 3 Related Classifications
HY-180403 Related Classifications
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