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Cat. No.: HY-19095

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TNP-351

TNP-351 is an antifolate. TNP-351, a dihydrofolate reductase (DHFR) inhibitor, has potent antitumor activity against not only leukemia cells but also solid tumor cells in vitro and in vivo.

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CAS No.: 125991-51-7
Formule: C₂₁H₂₄N₆O₅
Masse moléculaire:440.45

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

TNP-351 Chemical Structure

CAS No.: 125991-51-7

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

TNP-351 is an antifolate. TNP-351, a dihydrofolate reductase (DHFR) inhibitor, has potent antitumor activity against not only leukemia cells but also solid tumor cells in vitro and in vivo^[1].

IC₅₀ & Target

Antifolate, DHFR^[1]

In Vitro

TNP-351 inhibits the proliferation of mouse L1210 leukemia cells and human CCRF-CEM lymphoblastic leukemia cells with ED₅₀ values of 0.79 and 2.7 nM, respectively^[1].
The ED₅₀ values determined for the parent cell line CCRF-CEM, CCRFCEM R30/6 subline, CCRF-CEM R1, and CCRF-CEM R2 are 2.7, 5.8, 94 and 76 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

L1210 and CCRF-CEM cells
Concentration:

0.1, 0.3, 1, 3, and 10 nM for L1210 cells; 0.3, 1, 3, 10, and 30 for CCRF-CEM cells
Incubation Time:

48 hours for L1210 cells; 72 hours for CCRF-CEM cells
Result:

The ED₅₀ values were 0.79 and 2.7 nM for L1210 and CCRF-CEM cells, respectively.

Chemical Information

CAS No. 125991-51-7
Masse moléculaire 440.45
Formule C₂₁H₂₄N₆O₅
SMILES

O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(CCCC2=CNC3=NC(N)=NC(N)=C32)C=C1)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. F Itoh ,et al. Novel pyrrolo[2,3-d]pyrimidine Antifolate TNP-351: Cytotoxic Effect on Methotrexate-Resistant CCRF-CEM Cells and Inhibition of Transformylases of De Novo Purine Biosynthesis. Cancer Chemother Pharmacol. 1994;34(4):273-9. [Content Brief]

Calculators

Calculateur de molarité

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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TNP-351

Pemetrexed

Folinic acid calcium

Folinic acid

Pralatrexate

Pemetrexed (Standard)

Levoleucovorin Calcium

Levomefolate calcium

Pemetrexed disodium hemipenta hydrate

Pelitrexol

Folinic acid calcium salt pentahydrate

Calcium N5-methyltetrahydrofolate

LY309887

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Bioz

TNP-351

Pemetrexed

Folinic acid calcium

Folinic acid

Pralatrexate

Pemetrexed (Standard)

Levoleucovorin Calcium

Levomefolate calcium

Pemetrexed disodium hemipenta hydrate

Pelitrexol

Folinic acid calcium salt pentahydrate

Calcium N5-methyltetrahydrofolate

LY309887

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

TNP-351 Related Classifications

HY-19095 Related Classifications

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