TPN729
TPN729 is a selective phosphodiesterase type 5 (PDE5) inhibitor with an IC50 value of 2.28 nM. TPN729 affects erectile function and it can be used for the research of erectile dysfunction.
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- CAS No.: 936951-20-1
- Formule: C25H36N6O4S
- Masse moléculaire:516.66
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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PDE5 2.28 nM (IC50) |
PDE6 45.2 nM (IC50) |
PDE1 566 nM (IC50) |
PDE4 834 nM (IC50) |
PDE11 6090 nM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats with corpora cavernosa complete exposure[1]
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Dosage:1.25, 2.5 and 5.0 mg/kg
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Administration:Intraduodenal (i.d.) injection; 1.25, 2.5 and 5.0 mg/kg, once
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Result:Dose-dependently increased the maximum intracavernous pressure (ICP) and ICP/blood pressure (BP).
Chemical Information
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CAS No. 936951-20-1
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Masse moléculaire 516.66
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Formule C25H36N6O4S
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SMILES
O=S(C1=CC=C(OCCC)C(C(NC2=C3N(C)N=C2CCC)=NC3=O)=C1)(N(C)CCN4CCCC4)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TPN729 Related Classifications
HY-116808 Related Classifications
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