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Cat. No.: HY-P10878

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UK140

UK140 is the inhibitor for urokinase-type plasminogen activator (uPA) with K_i of 0.20 µM and 2.79 µM for huPA anf muPA. UK140 can be used in metastasis-related research.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₇₂H₁₀₅N₁₉O₂₅S₃
Masse moléculaire:1732.91

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

UK140 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références
Calculators
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Bioz

Activité biologique

Description

UK140 is the inhibitor for urokinase-type plasminogen activator (uPA) with K_i of 0.20 µM and 2.79 µM for huPA anf muPA. UK140 can be used in metastasis-related research^[1].

IC₅₀ & Target

K_i: 0.20 µM (huPA); 2.79 µM (muPA)

Chemical Information

Masse moléculaire 1732.91

Formule C₇₂H₁₀₅N₁₉O₂₅S₃

Sequence

Ala-Cys-Asn-Ser-Lys-Phe-Ser-Gly-Cys-Gly-Val-Asp-Pro-Ser-Ser-Cys-Gly (cyclized via TBMB and Cys2,9,16)

Sequence Shortening

ACNSKFSGCGVDPSSCG (cyclized via TBMB and Cys2,9,16)

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (258 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Mazzocato Y, et al., A novel genetically-encoded bicyclic peptide inhibitor of human urokinase-type plasminogen activator with better cross-reactivity toward the murine orthologue. Bioorg Med Chem. 2023 Nov 15;95:117499. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

=
Concentration Concentration

×
Volume Volume

×
Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

×

Volume _(start) Volume _(start)

=

Concentration _(final) Concentration _(final)

×

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

UK140 Related Classifications

HY-P10878 Related Classifications

Metabolic Enzyme/Protease

PAI-1

Aires thérapeutique

Cancer

Peptides

Peptide and Derivatives

Inhibitors and Substrates

Cancer

Cancer Targeted Therapy Cancer Metabolism and Metastasis

Bioz

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Keywords

UK140
UK 140
UK-140
PAI-1
Inhibitor
inhibitor
inhibit

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ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社

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UK140

Activité biologique

Description

IC50 & Target

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

UK140 Related Classifications

HY-P10878 Related Classifications

Bioz

Keywords

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IC₅₀ & Target