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Cat. No.: HY-168324

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UP158

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Based on 1 Customer Validation

UP158 enhances the activity of ATPase, and activates valosin-containing protein (VCP) with an EC₅₀ of 2.57 μM.

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Pureté: 99.88%
CAS No.: 489402-33-7
Formule: C₁₇H₁₇ClN₄O₂
Masse moléculaire:344.80

Stockage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

UP158 Chemical Structure

CAS No.: 489402-33-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

UP158 enhances the activity of ATPase, and activates valosin-containing protein (VCP) with an EC₅₀ of 2.57 μM^[1].

Chemical Information

CAS No. 489402-33-7
Appearance Solid
Masse moléculaire 344.80
Formule C₁₇H₁₇ClN₄O₂
Color White to off-white
SMILES

ClC1=CC2=C(NC3=C(N4CCC5(CC4)OCCO5)N=CN=C32)C=C1
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

DMSO : < 1 mg/mL (insoluble or slightly soluble)

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Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Phan JM, et al., VCP activator reverses nuclear proteostasis defects and enhances TDP-43 aggregate clearance in multisystem proteinopathy models. J Clin Invest. 2024 May 23;134(14):e169039. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

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Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références

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UP158

MCE Bioactive Compound Library