UPG-108
UPG-108, a peptide compound, is a non-competitive allosteric modulator of Urotensin II receptors (UTR). UPG-108 significantly enhances the efficacy of UTR agonists but reduces the potency of UTR agonists. UPG-111 efficiently induces calcium release and does not cause contraction of rat aortic rings without endothelial denudation. UPG-111 can be used to study various diseases related to the angiotensinergic system.
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- CAS No.: 3090686-88-4
- Formule: C65H88N14O17S2
- Masse moléculaire:1401.61
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Chemical Information
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CAS No. 3090686-88-4
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Masse moléculaire 1401.61
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Formule C65H88N14O17S2
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Sequence
Glu-Thr-Pro-Glu-Asp-{Pen}-Phe-{d-Trp}-{Orn}-Tyr-Cys-Val (Disulfide bridge: Pen-Cys)
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Sequence Shortening
ETPED-{Pen}-F-{d-Trp}-{Orn}-YCV (Disulfide bridge: Pen-Cys)
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UPG-108 Related Classifications
HY-P11258 Related Classifications
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- UPG-108
- 3090686-88-4
- UPG108
- UPG 108
- Urotensin Receptor
- Urotensin II receptor (UTR)
- Super-agonist
- Positive allosteric modulator (PAM)
- Lateral allostery
- GPCR multimer
- Structure-activity relationship (SAR)
- N-terminal peptide engineering
- Noncompetitive modulation
- Calcium mobilization
- Rat aorta contraction
- Inhibitor
- inhibitor
- inhibit