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Cat. No.: HY-118904

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VL-0395

VL-0395 is a CCK1 selective antagonist with IC₅₀ of 0.197 μM for CCK1 in rat pancreatic acinar cells.

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CAS No.: 620167-11-5
Formule: C₂₅H₂₁N₃O₄
Masse moléculaire:427.45

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

VL-0395 Chemical Structure

CAS No.: 620167-11-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Protocole (1)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

VL-0395 is a CCK1 selective antagonist with IC₅₀ of 0.197 μM for CCK1 in rat pancreatic acinar cells^[1].

Voir tous les produits spécifiques à Isoform Cholecystokinin Receptor :

CCKAR
CCKBR

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	197 nM Compound: VL-0395	Displacement of [111In]DTPA-Glu-Gly-[Tyr27(SO3H)]-CCK8 from human CCK1 receptor in A431 cells Displacement of [111In]DTPA-Glu-Gly-[Tyr27(SO3H)]-CCK8 from human CCK1 receptor in A431 cells	[PMID: 16610788]

Chemical Information

CAS No. 620167-11-5
Masse moléculaire 427.45
Formule C₂₅H₂₁N₃O₄
SMILES

O=C(C(CC1=CC=CC=C1)NC(C2=C(NC(C3=CC4=C(N3)C=CC=C4)=O)C=CC=C2)=O)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Varnavas A, et al. Anthranilic acid based CCK1 receptor antagonists: preliminary investigation on their second “touch point”[J]. European journal of medicinal chemistry, 2005, 40(6): 563-581. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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