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Cat. No.: HY-184905

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W1507

W1507 is an NH₂-TML-based linker-payload conjugate, in which the payload is Exatecan (HY-13631) and the linker is Mal-PEG4-Val-Ala-Ph-2,2-dimethylpropanoic acid (HY-184906). W1507 can be conjugated with Trastuzumab (HY-P9907) to synthesize the ADC Her2-W1507. Her2-W1507 exhibits in vivo anti-tumor activity. W1507 can be used for the research of gastric cancer, ovarian adenocarcinoma and Her2-amplified breast cancer.

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Formule: C₆₁H₇₅FN₈O₁₅
Masse moléculaire:1179.29

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Please store the product under the recommended conditions in the Certificate of Analysis.

W1507 Chemical Structure

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Drug-Linker Conjugates for ADC :

In Vitro

W1507 (5 mM; 1 h) is resistant to cathepsin B-mediated cleavage, with no detectable Exatecan (HY-13631) release from the linker-payload in a cell-free in vitro assay^[1].
Her2-W1507 (72 h) potently inhibits the proliferation of HER2-positive NCI-N87, SK-OV-3, and SK-BR-3 cells with IC₅₀ values of 48.49 nM, 88.30 nM, and 65.22 nM respectively, while showing minimal activity against HER2-negative MDA-MB-231 cells (IC₅₀ >500 nM) after 72 hours of incubation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Masse moléculaire 1179.29
Formule C₆₁H₇₅FN₈O₁₅
SMILES

O=C(N[C@@H](C(C)C)C(N[C@@H](C)C(NC1=CC=CC=C1CC(C)(C)C(N[C@H]2CCC3=C4C2=C(CN5C(C(COC([C@@]6(CC)O)=O)=C6C=C57)=O)C7=NC4=CC(F)=C3C)=O)=O)=O)CCOCCOCCOCCOCCNC(CCN8C(C=CC8=O)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Li X, et al. NH2-trimethyl lock (NH2-TML): a stable and effective adapter for exatecan-based antibody-drug conjugates. Bioorg Chem. 2026 Sep 5;179:110038. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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W1507

Voir tous les produits spécifiques à Isoform Drug-Linker Conjugates for ADC