WAAG-3R
WAAG-3R is a biological active peptide. (Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage. This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay. (Ex/Em = 340/420 nm)
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- Formule: C69H109N23O24
- Masse moléculaire:1644.74
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Chemical Information
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Masse moléculaire 1644.74
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Formule C69H109N23O24
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Sequence
{Abz}-Thr-Glu-Gly-Glu-Ala-Arg-Gly-Ser-Val-Ile-{Dap(Dnp)}-Lys-Lys-NH2
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Sequence Shortening
{Abz}-TEGEARGSVI-{Dap(Dnp)}-KK-NH2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. De Savi C, et al. The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis[J]. Bioorganic & medicinal chemistry letters, 2011, 21(5): 1376-1381. [Content Brief]
[2]. Hongfeng Deng, et al. Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT). J Med Chem. 2012 Aug 23;55(16):7061-79. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
WAAG-3R Related Classifications
HY-P5419 Related Classifications
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