WSL017
WSL017 is a cytochrome bd oxidase inhibitor with antibacterial activity against Mycobacterium tuberculosis. WSL017 can be used for the research of tuberculosis.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C17H19NOS
- Masse moléculaire:285.40
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
WSL017 (0.001-100 µM) competitively inhibits Mycobacterium tuberculosis cytochrome bd (Mtbd) in proteoliposomes with an IC50 of 1.4 µM by binding to the quinol-binding site[1].
WSL017 (0.001-100 µM) competitively inhibits Escherichia coli cytochrome bd (Ecbd) in proteoliposomes with an IC50 of 1.7 µM by binding to the quinol-binding site[1].
WSL017 (3 µM) does not inhibit Caldalkalibacillus thermarum type 2 NADH dehydrogenase (NDH2) activity, confirming its specific action on cytochrome bd oxidases[1].
WSL017 (100 µM) binds to the quinol oxidation site of dimeric Escherichia coli cytochrome bd (Ecbd) via hydrophobic interactions, stabilizing the Q-loop in a closed state to inhibit enzyme activity[1].
WSL017 (25 µM; 7 days) significantly impairs the growth of Mycobacterium tuberculosis H37ra cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mycobacterium tuberculosis H37ra cells
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Concentration:25 µM
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Incubation Time:7 days
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Result:Reduced growth to approximately 50% relative to control.
Significantly impaired the growth of Mycobacterium tuberculosis H37ra cells.
Chemical Information
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Masse moléculaire 285.40
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Formule C17H19NOS
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SMILES
CCC(NC1=CC=C(SC2=CC(C)=CC=C2C)C=C1)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
WSL017 Related Classifications
HY-184156 Related Classifications
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