2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Caf1-IN-1

Caf1-IN-1 (Compound 8j) is inhibitor for ribonuclease Caf1 with an IC50 of 0.59 µM. Caf1-IN-1 is also a weak inhibitor for poly(A)-specific ribonuclease (PARN) with IC50 of 23.9 µM.

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Caf1-IN-1

Caf1-IN-1 Estructura química

No. CAS : 1807775-88-7

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Caf1-IN-1 Related Antibodies

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Descripciòn

Caf1-IN-1 (Compound 8j) is inhibitor for ribonuclease Caf1 with an IC50 of 0.59 µM. Caf1-IN-1 is also a weak inhibitor for poly(A)-specific ribonuclease (PARN) with IC50 of 23.9 µM[1].

IC50 & Target

IC50: 0.59 µM (Caf1), 23.9 µM (PARN)
Peso molecular

357.41

Fòrmula

C18H23N5O3
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=C(N(CCCN(C)C)C(N1O)=O)N=CN2CCC3=CC=CC=C3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 125 mg/mL (349.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7979 mL 13.9895 mL 27.9791 mL
5 mM 0.5596 mL 2.7979 mL 5.5958 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7979 mL 13.9895 mL 27.9791 mL 69.9477 mL
5 mM 0.5596 mL 2.7979 mL 5.5958 mL 13.9895 mL
10 mM 0.2798 mL 1.3990 mL 2.7979 mL 6.9948 mL
15 mM 0.1865 mL 0.9326 mL 1.8653 mL 4.6632 mL
20 mM 0.1399 mL 0.6995 mL 1.3990 mL 3.4974 mL
25 mM 0.1119 mL 0.5596 mL 1.1192 mL 2.7979 mL
30 mM 0.0933 mL 0.4663 mL 0.9326 mL 2.3316 mL
40 mM 0.0699 mL 0.3497 mL 0.6995 mL 1.7487 mL
50 mM 0.0560 mL 0.2798 mL 0.5596 mL 1.3990 mL
60 mM 0.0466 mL 0.2332 mL 0.4663 mL 1.1658 mL
80 mM 0.0350 mL 0.1749 mL 0.3497 mL 0.8743 mL
100 mM 0.0280 mL 0.1399 mL 0.2798 mL 0.6995 mL
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Caf1-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Caf1-IN-11807775-88-7DNA/RNA SynthesisInhibitorinhibitorinhibit

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Nombre del producto:
Caf1-IN-1
Cat. No.:
HY-158970
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