10179-57-4
10179-57-4
Chemical Structure
MLS-573151
Synonym(s): MLS000573151
- CAS No.: 10179-57-4
- Formula:C21H19N3O2S
- Molecular Weight:377.46
IUPAC Name: 4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
InChIKey: OPPCVEVPKHRJNY-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(N2N=C(C3=CC=CC=C3)CC2C4=CC=CC=C4)C=C1)(N)=O
Biological Activity: MLS-573151 (MLS000573151) is a selective GTPase Cdc42 inhibitor with an EC50 of 2 μM. MLS-573151 is inactive against other GTPases family members, such as Rab2, Rab7, H-Ras, Rac1, Rac 2 and RhoA wild-type. MLS-573151 acts by blocking the binding of GTP to Cdc42[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MLS-573151 | 99.66% | MLS-573151 (MLS000573151) is a selective GTPase Cdc42 inhibitor with an EC50 of 2 μM. MLS-573151 is inactive against other GTPases family members, such as Rab2, Rab7, H-Ras, Rac1, Rac 2 and RhoA wild-type. MLS-573151 acts by blocking the binding of GTP to Cdc42. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.83
HY-12755ML141 -
Similarity Score 0.79
HY-153611ARC12 -
Similarity Score 0.77
HY-W2692701,3,5-Triphenyl-2-pyrazoline -
Similarity Score 0.74
HY-179021COX-2/15-LOX-IN-7 -
Similarity Score 0.72
HY-136379CID44216842 -
Similarity Score 0.67
HY-162575Anticancer agent 231 -
Similarity Score 0.60
HY-147997EGFR-IN-68 -
Similarity Score 0.60
HY-154438RDR 02308 -
Similarity Score 0.57
HY-D3255CTAP-1 -
Explore the MedChemAI to find more analogs
References
- [1]. Zurab Surviladze, et al. Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay. J Biomol Screen. 2010 Jan;15(1):10-20. [Content Brief]
- [2]. Fan Mao, et al. Transcriptomic Evidence Reveals the Molecular Basis for Functional Differentiation of Hemocytes in a Marine Invertebrate, Crassostrea gigas. Front Immunol. 2020 May 27;11:911. [Content Brief]
