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Cat. No.: HY-147997

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EGFR-IN-68

EGFR-IN-68 (Compound 8d) is a potent EGFR inhibitor with an IC₅₀ of 0.33 μM. EGFR-IN-68 shows anticancer activity.

For research use only. We do not sell to patients.

CAS No.: 2416925-03-4
Formula: C₂₄H₂₂N₂O
Molecular Weight:354.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

EGFR-IN-68 Chemical Structure

CAS No.: 2416925-03-4

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Help & FAQs
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Bioz

Biological Activity

Description

EGFR-IN-68 (Compound 8d) is a potent EGFR inhibitor with an IC₅₀ of 0.33 μM. EGFR-IN-68 shows anticancer activity^[1].

All EGFR Isoforms :

In Vitro

EGFR-IN-68 (Compound 8d) shows cytotoxicity with IC₅₀ values of 3.79 ± 0.04 μM and 25.56 ± 1.59 μM against MCF-7 and WI-38, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2416925-03-4
Molecular Weight 354.44
Formula C₂₄H₂₂N₂O
SMILES

COC1=CC=C(N2N=C(C3=CC=CC=C3)CC2/C=C/C4=CC=CC=C4)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. George RF, et al. Some 1,3,5-trisubstituted pyrazoline derivatives targeting breast cancer: Design, synthesis, cytotoxic activity, EGFR inhibition and molecular docking. Bioorg Chem. 2020 Jun;99:103780. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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EGFR-IN-68

All EGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

EGFR-IN-68 Related Classifications

HY-147997 Related Classifications