103-23-1
Chemical Structure
Bis(2-ethylhexyl) adipate
Synonym(s): NSC 56775
- CAS No.: 103-23-1
- Formula:C22H42O4
- Molecular Weight:370.57
IUPAC Name: bis(2-ethylhexyl) adipate
InChIKey: SAOKZLXYCUGLFA-UHFFFAOYSA-N
SMILES: CCCCC(COC(CCCCC(OCC(CCCC)CC)=O)=O)CC
Biological Activity: Bis(2-ethylhexyl) adipate (NSC 56775) is an aliphatic plasticizer with certain toxicity. Bis(2-ethylhexyl) adipate is a rodent hepatic peroxisome proliferator that dose-dependently increases relative liver weight in rodents, upregulates palmitoyl-CoA oxidase (PCO) activity, and induces hepatocyte hypertrophy and glycogen loss. Long-term exposure to Bis(2-ethylhexyl) adipate induces hepatocellular tumors in B6C3F1 mice. Bis(2-ethylhexyl) adipate induces maternal gestational toxicity and reduced offspring birth weight in a prenatal-postnatal exposure Wistar rat model. Bis(2-ethylhexyl) adipate can be used in metabolism-related research and organic synthesis-related research[1][2][3].
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Bis(2-ethylhexyl) adipate | Bis(2-ethylhexyl) adipate (NSC 56775) is an aliphatic plasticizer with certain toxicity. Bis(2-ethylhexyl) adipate is a rodent hepatic peroxisome proliferator that dose-dependently increases relative liver weight in rodents, upregulates palmitoyl-CoA oxidase (PCO) activity, and induces hepatocyte hypertrophy and glycogen loss. Long-term exposure to Bis(2-ethylhexyl) adipate induces hepatocellular tumors in B6C3F1 mice. Bis(2-ethylhexyl) adipate induces maternal gestational toxicity and reduced offspring birth weight in a prenatal-postnatal exposure Wistar rat model. Bis(2-ethylhexyl) adipate can be used in metabolism-related research and organic synthesis-related research. | |||||||||||||||||||||
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Bis(2-ethylhexyl) adipate-d8 | Bis(2-ethylhexyl) adipate-d8 is the deuterium labeled Bis(2-ethylhexyl) adipate. | |||||||||||||||||||||
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References
- [1]. Silva MJ, et al. In vitro metabolites of di-2-ethylhexyl adipate (DEHA) as biomarkers of exposure in human biomonitoring applications. Chemical research in toxicology. 2013 Oct 21;26(10):1498-502.
- [2]. Keith Y, et al. Peroxisome proliferation due to di (2-ethylhexyl) adipate, 2-ethylhexanol and 2-ethylhexanoic acid. Archives of toxicology. 1992;66(5):321-6.
- [3]. Dalgaard M, et al. Di(2-ethylhexyl) adipate (DEHA) induced developmental toxicity but not antiandrogenic effects in pre- and postnatally exposed Wistar rats. Reproductive toxicology (Elmsford, N.Y.). 2003;17(2):163-70.
