103-85-5
103-85-5
Chemical Structure
Phenylthiourea
Synonym(s): Phenylthiocarbamide
- CAS No.: 103-85-5
- Formula:C7H8N2S
- Molecular Weight:152.22
IUPAC Name: 1-phenylthiourea
InChIKey: FULZLIGZKMKICU-UHFFFAOYSA-N
SMILES: S=C(NC1=CC=CC=C1)N
Biological Activity: Phenylthiourea (Phenylthiocarbamide) is an inhibitor for phenoloxidase. Phenylthiourea inhibits enzymatic oxidation of DOPA by phenoloxidase (Ki = 0.21 μM). Phenylthiourea is an effective inhibitor for tyrosinase. Phenylthiourea can lead to graying of hair in black rats due to the interference with melanin formation[1][2].
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Phenylthiourea | 99.26% | Phenylthiourea (Phenylthiocarbamide) is an inhibitor for phenoloxidase. Phenylthiourea inhibits enzymatic oxidation of DOPA by phenoloxidase (Ki = 0.21 μM). Phenylthiourea is an effective inhibitor for tyrosinase. Phenylthiourea can lead to graying of hair in black rats due to the interference with melanin formation. | ||||||||||||||||||||
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References
- [1]. Ryazanova AD, et al. The phenylthiourea is a competitive inhibitor of the enzymatic oxidation of DOPA by phenoloxidase. J Enzyme Inhib Med Chem. 2012 Feb;27(1):78-83. [Content Brief]
- [2]. Frederick Bernheim & Mary L.C. Bernheim (1942) THE ACTION OF PHENYLTHIOCARBAMIDE ON TYROSINASE, Journal of Biological Chemistry, Volume 145, Issue 1, Pages 213-217, ISSN 0021-9258.
