112-84-5
Chemical Structure
Erucamide
Synonym(s): cis-13-Docosenamide
- CAS No.: 112-84-5
- Formula:C22H43NO
- Molecular Weight:337.58
IUPAC Name: (Z)-docos-13-enamide
InChIKey: UAUDZVJPLUQNMU-KTKRTIGZSA-N
SMILES: CCCCCCCC/C=C\CCCCCCCCCCCC(N)=O
Biological Activity: Erucamide is an orally active, blood-brain barrier-permeable TMEM19 ligand and T3SS inhibitor. Erucamide exerts retinal neuroprotective effects in mouse models of retinal degeneration. Erucamide attenuates depression- and anxiety-like behaviors in mice.\n\nErucamide binds to the conserved hydrophobic pocket in HrcC, disrupts its outer membrane localization, and blocks T3SS-mediated effector protein secretion in Gram-negative pathogenic bacteria. Erucamide enhances the antimicrobial immunity of plants against pathogenic bacteria. Erucamide can be used in research related to retinitis pigmentosa, anxiety and depression, bacterial wilt, and bacterial blight[1][2][3][4].
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Erucamide | 99.32% | Erucamide is an orally active, blood-brain barrier-permeable TMEM19 ligand and T3SS inhibitor. Erucamide exerts retinal neuroprotective effects in mouse models of retinal degeneration. Erucamide attenuates depression- and anxiety-like behaviors in mice.\n\nErucamide binds to the conserved hydrophobic pocket in HrcC, disrupts its outer membrane localization, and blocks T3SS-mediated effector protein secretion in Gram-negative pathogenic bacteria. Erucamide enhances the antimicrobial immunity of plants against pathogenic bacteria. Erucamide can be used in research related to retinitis pigmentosa, anxiety and depression, bacterial wilt, and bacterial blight. | ||||||||||||||||||||
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Erucamide (Standard) | ≥98% | Erucamide (Standard) is the analytical standard of Erucamide. This product is intended for research and analytical applications. Erucamide inhibits intestinal diarrhea.Erucamide also regulates the volume of body fluids in other organs. Erucamide has the ability to promote angiogenesis. | ||||||||||||||||||||
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- [1]. Hamberger A, et al. Erucamide as a modulator of water balance: new function of a fatty acid amide. Neurochem Res.2003 Feb;28(2):177-85. [Content Brief]
- [2]. Li MM, et al. Antidepressant and anxiolytic-like behavioral effects of erucamide, a bioactive fatty acid amide, involving the hypothalamus-pituitary-adrenal axis in mice. Neurosci Lett. 2017 Feb 15;640:6-12. [Content Brief]
- [3]. Wei G, et al. Erucamide regulates retinal neurovascular crosstalk. bioRxiv [Preprint]. 2025 Sep 7:2025.09.02.673793. [Content Brief]
- [4]. Miao P, et al. A widespread plant defense compound disarms bacterial type III injectisome assembly. Science. 2025;387(6737):eads0377. [Content Brief]
Keywords
