Erucamide-d17
Erucamide-d17 (cis-13-Docosenamide-d17) is the deuterated-labeled Erucamide (HY-W009123). Erucamide is an orally active, blood-brain barrier-permeable TMEM19 ligand and T3SS inhibitor. Erucamide exerts retinal neuroprotective effects in mouse models of retinal degeneration. Erucamide attenuates depression- and anxiety-like behaviors in mice.\n\nErucamide binds to the conserved hydrophobic pocket in HrcC, disrupts its outer membrane localization, and blocks T3SS-mediated effector protein secretion in Gram-negative pathogenic bacteria. Erucamide enhances the antimicrobial immunity of plants against pathogenic bacteria. Erucamide can be used in research related to retinitis pigmentosa, anxiety and depression, bacterial wilt, and bacterial blight.
For research use only. We do not sell to patients.
- Formula: C22H26D17NO
- Molecular Weight:354.69
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 112-84-5
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Molecular Weight 354.69
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Formula C22H26D17NO
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SMILES
NC(CCCCCCCCCCC/C=C\C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O
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Synonyms
cis-13-Docosenamide-d17
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hamberger A, et al. Erucamide as a modulator of water balance: new function of a fatty acid amide. Neurochem Res.2003 Feb;28(2):177-85. [Content Brief]
[2]. Li MM, et al. Antidepressant and anxiolytic-like behavioral effects of erucamide, a bioactive fatty acid amide, involving the hypothalamus-pituitary-adrenal axis in mice. Neurosci Lett. 2017 Feb 15;640:6-12. [Content Brief]
[3]. Wei G, et al. Erucamide regulates retinal neurovascular crosstalk. bioRxiv [Preprint]. 2025 Sep 7:2025.09.02.673793. [Content Brief]
[4]. Miao P, et al. A widespread plant defense compound disarms bacterial type III injectisome assembly. Science. 2025;387(6737):eads0377. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Erucamide-d17 Related Classifications
HY-W009123S Related Classifications
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