1189936-99-9
1189936-99-9
Chemical Structure
Pyrimethamine-d3
- CAS No.: 1189936-99-9
- Formula:C12H10D3ClN4
- Molecular Weight:251.73
IUPAC Name: 5-(4-chlorophenyl)-6-(ethyl-2,2,2-d3)pyrimidine-2,4-diamine
InChIKey: WKSAUQYGYAYLPV-FIBGUPNXSA-N
SMILES: C(C([2H])([2H])[2H])C=1C(=C(N)N=C(N)N1)C2=CC=C(Cl)C=C2
Biological Activity: Pyrimethamine-d3 is the deuterium labeled Pyrimethamine. Pyrimethamine is a medication used for protozoal infections; interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR)[1][2].
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Pyrimethamine-d3 | 99.90% | Pyrimethamine-d3 is the deuterium labeled Pyrimethamine. Pyrimethamine is a medication used for protozoal infections; interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR). | ||||||||||||||||||||
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Pyrimethamine (Standard) | ≥98% | Pyrimethamine (Standard) is the analytical standard of Pyrimethamine. This product is intended for research and analytical applications. Pyrimethamine (Pirimecidan) is a potent, orally active dihydrofolate reductase (DHFR) inhibitor. Pyrimethamine is an antimalarial agent. Pyrimethamine affects the nucleoprotein metabolism of malarial parasites by interference in the folic–folinic acid systems and affects cell division by inhibiting the conversion of dihydrofolate to tetrahydrofolate. | ||||||||||||||||||||
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Pyrimethamine | 99.99% | Pyrimethamine (Pirimecidan) is a potent, orally active dihydrofolate reductase (DHFR) inhibitor. Pyrimethamine is an antimalarial agent. Pyrimethamine affects the nucleoprotein metabolism of malarial parasites by interference in the folic–folinic acid systems and affects cell division by inhibiting the conversion of dihydrofolate to tetrahydrofolate. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Basco LK, et al. In vitro activity of pyrimethamine, cycloguanil, and other antimalarial drugs against African isolates and clones of Plasmodium falciparum. Am J Trop Med Hyg. 1994 Feb; 50(2):193-9. [Content Brief]
