1216420-11-9
Chemical Structure
Desmethyl Erlotinib-d4
- CAS No.: 1216420-11-9
- Formula:C21H17D4N3O4
- Molecular Weight:383.43
IUPAC Name: 2-((4-((3-ethynylphenyl-2,4,5,6-d4)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethan-1-ol
InChIKey: KOQIAZNBAWFSQM-GTNXRJHWSA-N
SMILES: N(C=1C2=C(C=C(OCCOC)C(OCCO)=C2)N=CN1)C3=C(C(C#C)=C(C(=C3[2H])[2H])[2H])[2H]
Biological Activity: Desmethyl Erlotinib-d4 is the deuterium labeled Desmethyl Erlotinib. Desmethyl Erlotinib (OSI-420 free base) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor[1][2]. Desmethyl Erlotinib-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Desmethyl Erlotinib-d4 | Desmethyl Erlotinib-d4 is the deuterium labeled Desmethyl Erlotinib. Desmethyl Erlotinib (OSI-420 free base) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor. Desmethyl Erlotinib-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | |||||||||||||||||||||
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Desmethyl Erlotinib (Standard) | ≥98% | Antioxidant 1024 (Standard) is the analytical standard of Antioxidant 1024. This product is intended for research and analytical applications. Antioxidant 1024 (MD 1024) is an antioxidant agent and metal deactivator. | ||||||||||||||||||||
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Desmethyl Erlotinib-d4-1 | Desmethyl Erlotinib-d4-1 (OSI-420-d4-1 (free base); CP-373420-d4-1) is deuterium-labeled Desmethyl Erlotinib (HY-13256A). | |||||||||||||||||||||
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Desmethyl Erlotinib | 98.77% | Desmethyl Erlotinib (OSI-420 free base) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor. Desmethyl Erlotinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Thappali SR, et al. Simultaneous Determination of Celecoxib, Erlotinib, and its Metabolite Desmethyl-Erlotinib (OSI-420) in Rat Plasma by Liquid chromatography/Tandem Mass Spectrometry with Positive/Negative Ion-Switching Electrospray Ionisation.Sci Pharm. 2012 Jul-Sep;80(3):633-46. [Content Brief]
