131-53-3
131-53-3
Chemical Structure
Dioxybenzone
Synonym(s): Benzophenone-8; UV-24
- CAS No.: 131-53-3
- Formula:C14H12O4
- Molecular Weight:244.24
IUPAC Name: (2-hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)methanone
InChIKey: MEZZCSHVIGVWFI-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(OC)C=C1O)C2=CC=CC=C2O
Biological Activity: Dioxybenzone (Benzophenone-8; UV-24) is an organic compound used to block UVB and short-wave UVA (ultraviolet) radiation. Dioxybenzone has orally activity. Dioxybenzone exhibits estrogenic disrupting effect. Dioxybenzone up-regulates inflammatory cytokines. Dioxybenzone can be used for cancer, reproductive system disease and inflammatory disease study[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Dioxybenzone | 99.86% | Dioxybenzone (Benzophenone-8; UV-24) is an organic compound used to block UVB and short-wave UVA (ultraviolet) radiation. Dioxybenzone has orally activity. Dioxybenzone exhibits estrogenic disrupting effect. Dioxybenzone up-regulates inflammatory cytokines. Dioxybenzone can be used for cancer, reproductive system disease and inflammatory disease study. | ||||||||||||||||||||
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Dioxybenzone (Standard) | ≥98% | Dioxybenzone (Standard) is the analytical standard of Dioxybenzone. This product is intended for research and analytical applications. Dioxybenzone (Benzophenone-8; UV-24) is an organic compound used to block UVB and short-wave UVA (ultraviolet) radiation. Dioxybenzone has orally activity. Dioxybenzone exhibits estrogenic disrupting effect. Dioxybenzone up-regulates inflammatory cytokines. Dioxybenzone can be used for cancer, reproductive system disease and inflammatory disease study. | ||||||||||||||||||||
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Dioxybenzone-d3 | Dioxybenzone-d3 is deuterium labeled Dioxybenzone. Dioxybenzone (Benzophenone-8; UV-24) is an organic compound used to block UVB and short-wave UVA (ultraviolet) radiation. Dioxybenzone has orally activity. Dioxybenzone exhibits estrogenic disrupting effect. Dioxybenzone up-regulates inflammatory cytokines. Dioxybenzone can be used for cancer, reproductive system disease and inflammatory disease study. | |||||||||||||||||||||
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2,4'-Dihydroxybenzophenone-1 | 99.63% | 2,4'-Dihydroxybenzophenone ((Z)-SU4312) exhibited estrogenic activities. 2,4'-Dihydroxybenzophenone has oral bioactivity that can effectively protect C57BL/6J mice from Acetaminophen (HY-66005, APAP)-induced hepatotoxicity. | ||||||||||||||||||||
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Oxybenzone (Standard) | 99.92% | Oxybenzone (Standard) is the analytical standard of Oxybenzone. This product is intended for research and analytical applications. Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells. | ||||||||||||||||||||
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Mexenone (Standard) | ≥98% | Mexenone (Standard) is the analytical standard of Mexenone. This product is intended for research and analytical applications. Mexenone is a potent benzophenone-type UV filter. Mexenone is used for sunscreening agent. | ||||||||||||||||||||
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Cotoin | 99.90% | Cotoin is a natural product isolated from the stem bark of Garcinia virgate. | ||||||||||||||||||||
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Cearoin | 99.09% | Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK. | ||||||||||||||||||||
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2,5,2'-Trihydroxy-4-methoxybenzophenone | 2,5,2'-Trihydroxy-4-methoxybenzophenone is a natural phenolic compound. | |||||||||||||||||||||
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2,4′-Dihydroxybenzophenone | 98.00% | 2,4′-Dihydroxybenzophenone (Ultraviolet absorber UV-0) occupies the hydrophobic pocket of MD2 and blocks the dimerization of TLR4. 2,4′-Dihydroxybenzophenone inhibits the LPS induced mtROS production, and LPS induced inflammatory response by downregulating pro-inflammatory mediators and decreasing the expression of MyD88, p-IRAK4, and NF-κB. 2,4′-Dihydroxybenzophenone is also a UV absorber. | ||||||||||||||||||||
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2,4-Dihydroxybenzophenone-13C6 | 2,4-Dihydroxybenzophenone-13C6 (Ultraviolet absorber UV-0-13C6) is the 13C- and deuterium labeled (2,4-Dihydroxyphenyl)(phenyl)methanone. | |||||||||||||||||||||
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Benzophenone-2 | 99.66% | Benzophenone-2 (2,2',4,4'-Tetrahydroxybenzophenone) is an organic ultraviolet absorber that is widely used in personal care products and industrial products such as plastics and coatings. Benzophenone-2 is an endocrine disruptor that can interfere with estrogen receptors (ERα receptor) and pregnane X receptor (PXR receptor) activity, leading to reproductive toxicity, immune disorders, and metabolic abnormalities. Benzophenone-2 can inhibit the activity of α-glucosidase (IC50 = 49.72 μM), and can be used for research on diabetes. | ||||||||||||||||||||
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(2,6-Dihydroxy-4-methoxyphenyl)(4-hydroxyphenyl)methanone | (2,6-Dihydroxy-4-methoxyphenyl)(4-hydroxyphenyl)methanone is a Phenols product that can be isolated from the rhizomes of Anemarrhena asphodeloides BUNGE.. | |||||||||||||||||||||
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References
- [1]. Rao GS, et al. Oral chemoprevention of skin cancer in mice by benzophenone sunscreens dioxybenzone and octabenzone in drinking water. Anticancer Res. 2013 Jun;33(6):2535-40. [Content Brief]
- [2]. Zhan T, et al. Transcriptome aberration in mice uterus associated with steroid hormone response and inflammation induced by dioxybenzone and its metabolites. Environ Pollut. 2021 Oct 1;286:117294. [Content Brief]
- [3]. Sherwood VF, et al. Altered UV absorbance and cytotoxicity of chlorinated sunscreen agents. Cutan Ocul Toxicol. 2012 Dec;31(4):273-9. [Content Brief]
