133-67-5
133-67-5
Chemical Structure
Trichlormethiazide
- CAS No.: 133-67-5
- Formula:C8H8Cl3N3O4S2
- Molecular Weight:380.66
IUPAC Name: 6-chloro-3-(dichloromethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide
InChIKey: LMJSLTNSBFUCMU-UHFFFAOYSA-N
SMILES: O=S(C1=C(Cl)C=C(C2=C1)NC(C(Cl)Cl)NS2(=O)=O)(N)=O
Biological Activity: Trichlormethiazide is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Trichlormethiazide | 98.54% | Trichlormethiazide is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model. | ||||||||||||||||||||
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Trichlormethiazide (Standard) | 98.11% | Trichlormethiazide (Standard) is the analytical standard of Trichlormethiazide. This product is intended for research and analytical applications. Trichlormethiazide is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model. | ||||||||||||||||||||
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Cyclopenthiazide | 98.40% | Cyclopenthiazide is a benzothiadiazine diuretic with antihypertensive properties. Cyclopenthiazide exerts a diuretic effect by inhibiting the reabsorption of sodium chloride and water at the distal renal tubules. Cyclopenthiazide increases the excretory capacity of the rat kidney. | ||||||||||||||||||||
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Epitizide | 98.32% | Epitizide, a benzothiadiazine, commonly found in combination Triamterene (HY-B0575), is used to produce diuresis. | ||||||||||||||||||||
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Buthiazide | 98.87% | Buthiazide (Butizide) is a diuretic compound that can be used for high blood pressure research. | ||||||||||||||||||||
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Ethiazide | Ethiazide is a thiazole diuretic which inhibits renal reabsorption of sodium and water, thereby increasing urine excretion, reducing fluid retention, and lowering blood volume and blood pressure. Ethiazide can be used for cardiovascular research. | |||||||||||||||||||||
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Trichlormethiazide sodium | Trichlormethiazide sodium is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide sodium increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model. | |||||||||||||||||||||
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Hydrochlorothiazide | 99.46% | Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect. | ||||||||||||||||||||
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Hydrochlorothiazide-13C6 | 98.76% | Hydrochlorothiazide-13C6 is the 13C labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect. | ||||||||||||||||||||
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Methyclothiazide (Standard) | ≥98% | Methyclothiazide (Standard) is the analytical standard of Methyclothiazide. This product is intended for research and analytical applications. Methyclothiazide is an orally active antihypertensive agent and a diuretic agent. Methyclothiazide leads to a reduction of the vascular response to the action of endogenous vasoconstricting stimuli, such as Norepinephrine (HY-13715). Methyclothiazide is against voltage-dependent Ca-channel (VDCC) activity in vitro. | ||||||||||||||||||||
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Altizide | 99.94% | Altizide (Althiazide) is an orally active diuretic. Altizide can be used in studies of oedema and hypertension. | ||||||||||||||||||||
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(-)-Altizide | (-)-Altizide is the levorotatory enantiomer of Altizide (HY-B1254). Altizide is an orally active diuretic. Altizide can be used in studies of oedema and hypertension. | |||||||||||||||||||||
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References
- [1]. K Yao, et al. Diuretic effects of KW-3902, a novel adenosine A1-receptor antagonist, in various models of acute renal failure in rats. Jpn J Pharmacol. 1994 Apr;64(4):281-8. [Content Brief]
- [2]. J R Ballew, et al. Characterization of the antihypertensive effect of a thiazide diuretic in angiotensin II-induced hypertension. J Hypertens. 2001 Sep;19(9):1601-6. [Content Brief]
