1346604-90-7
1346604-90-7
Chemical Structure
Fingolimod-d4 hydrochloride
Synonym(s): FTY720-d4
- CAS No.: 1346604-90-7
- Formula:C19H30D4ClNO2
- Molecular Weight:347.96
IUPAC Name: 2-amino-2-(4-octylphenethyl)propane-1,1,3,3-d4-1,3-diol hydrochloride
InChIKey: SWZTYAVBMYWFGS-JWIOGAFXSA-N
SMILES: OC([2H])([2H])C(C([2H])([2H])O)(N)CCC1=CC=C(C=C1)CCCCCCCC.Cl[H]
Biological Activity: Fingolimod-d4 (hydrochloride) is the deuterium labeled Fingolimod hydrochloride. Fingolimod hydrochloride (FTY720) is a brain-penetrant sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride (FTY720) also is a pak1 activator, a immunosuppressant[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Fingolimod-d4 hydrochloride | 99.0% | Fingolimod-d4 (hydrochloride) is the deuterium labeled Fingolimod hydrochloride. Fingolimod hydrochloride (FTY720) is a brain-penetrant sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride (FTY720) also is a pak1 activator, a immunosuppressant. | ||||||||||||||||||||
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Fingolimod hydrochloride (Standard) | ≥98% | Fingolimod (hydrochloride) (Standard) is the analytical standard of Fingolimod (hydrochloride). This product is intended for research and analytical applications. Fingolimod hydrochloride (FTY720), an analog of sphingosine, is a potent sphingosine 1-phosphate (S1P) receptors modulator. Fingolimod hydrochloride is phosphorylated by sphingosine kinases, particularly by SK2, and then binds S1PR1, 3, 4, and 5. Fingolimod hydrochloride induces the internalization of S1P1, and consequently, inhibits S1P activity. Fingolimod hydrochloride also is a pak1 activator. | ||||||||||||||||||||
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Fingolimod hydrochloride | 99.94% | Fingolimod (FTY720) hydrochloride is a sphingosine 1-phosphate (S1P) antagonist with IC50 of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride is also a pak1 activator and immunosuppressant. | ||||||||||||||||||||
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References
