1354448-60-4
1354448-60-4
Chemical Structure
KH-CB20
- CAS No.: 1354448-60-4
- Formula:C15H13Cl2N3O2
- Molecular Weight:338.19
IUPAC Name: ethyl (E)-3-(2-amino-1-cyanovinyl)-6,7-dichloro-1-methyl-1H-indole-2-carboxylate
InChIKey: CXJCGSPAPOTTSF-VURMDHGXSA-N
SMILES: CCOC(C1=C(C2=C(C(Cl)=C(C=C2)Cl)N1C)/C(C#N)=C\N)=O
Biological Activity: KH-CB20, an E/Z mixture, is a potent and selective inhibitor of CLK1 and the closely related isoform CLK4, with an IC50 of 16.5 nM for CLK1. KH-CB20 can also inhibit DYRK1A (IC50=57.8 nM) and CLK3 (IC50=488 nM)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KH-CB20 | 99.80% | KH-CB20, an E/Z mixture, is a potent and selective inhibitor of CLK1 and the closely related isoform CLK4, with an IC50 of 16.5 nM for CLK1. KH-CB20 can also inhibit DYRK1A (IC50=57.8 nM) and CLK3 (IC50=488 nM). | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 1.00
HY-12828KH-CB19 -
Similarity Score 0.53
HY-B0376Mecarbinate -
Similarity Score 0.53
HY-124834Nrf2 activator-10 -
Similarity Score 0.49
HY-W009757Ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate -
Similarity Score 0.49
HY-16312MDL-29951 -
Similarity Score 0.49
HY-W092987Ethyl 4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylate -
Similarity Score 0.49
HY-103110AST1936 oxalate -
Similarity Score 0.48
HY-118403CK2-IN-12 -
Similarity Score 0.48
HY-116850Oxagrelate -
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