163239-22-3
163239-22-3
Chemical Structure
680C91
- CAS No.: 163239-22-3
- Formula:C15H11FN2
- Molecular Weight:238.26
IUPAC Name: (E)-6-fluoro-3-(2-(pyridin-3-yl)vinyl)-1H-indole
InChIKey: YBSDQTBCNYWBMX-ONEGZZNKSA-N
SMILES: FC1=CC2=C(C=C1)C(/C=C/C3=CC=CN=C3)=CN2
Biological Activity: 680C91 is an orally active, selective tryptophan 2,3-dioxygenase (TDO) inhibitor with a Ki of 51 nM. TDO is the key enzyme of tryptophan catabolism. 680C91 can be used for the research of cancer immunotherapy and Alzheimer’s Disease[1][2][3][4].
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680C91 | 99.39% | 680C91 is an orally active, selective tryptophan 2,3-dioxygenase (TDO) inhibitor with a Ki of 51 nM. TDO is the key enzyme of tryptophan catabolism. 680C91 can be used for the research of cancer immunotherapy and Alzheimer’s Disease. | ||||||||||||||||||||
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680C91 (Standard) | ≥98% | 680C91 (Standard) is the analytical standard of 680C91 (HY-108681). This product is intended for research and analytical applications. 680C91 is an orally active, selective tryptophan 2,3-dioxygenase (TDO) inhibitor with a Ki of 51 nM. TDO is the key enzyme of tryptophan catabolism. 680C91 can be used for the research of cancer immunotherapy and Alzheimer’s Disease. | ||||||||||||||||||||
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References
- [1]. Li DD, et al. Differential expression and regulation of Tdo2 during mouse decidualization. J Endocrinol. 2013 Dec 2;220(1):73-83. [Content Brief]
- [2]. M Salter, et al. The effects of an inhibitor of tryptophan 2,3-dioxygenase and a combined inhibitor of tryptophan 2,3-dioxygenase and 5-HT reuptake in the rat. Neuropharmacology. 1995 Feb;34(2):217-27. [Content Brief]
- [3]. M Salter, et al. The effects of a novel and selective inhibitor of tryptophan 2,3-dioxygenase on tryptophan and serotonin metabolism in the rat. Biochem Pharmacol. 1995 May 17;49(10):1435-42. [Content Brief]
- [4]. Dang-Dang Li, et al. Differential expression and regulation of Tdo2 during mouse decidualization. J Endocrinol. 2013 Dec 2;220(1):73-83.
